ArticleNature communications2016
The multicellularity genes of dictyostelid social amoebas.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Integrated Symbiotic Pleiotropy: Long Non-Coding RNAs and Disordered Proteins Interweaving the Functional Layers of the Eukaryotic Cell.International journal of molecular sciences · 2026Review
- Genome editing across Dictyostelia species enables comparative functional genetics of social amoebas.Scientific reports · 2026Article
- Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptomics informed discovery of developmentally essential transcription factors.Biology open · 2025Article
- The Acrasis kona genome and developmental transcriptomes reveal deep origins of eukaryotic multicellular pathways.Nature communications · 2024Article
- Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia.BMC ecology and evolution · 2023Article
- On the origin of the functional versatility of macrophages.Frontiers in physiology · 2023Article
- Adenylate cyclase A amplification and functional diversification during Polyspondylium pallidum development.EvoDevo · 2022Article
- Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways.Journal of the Royal Society, Interface · 2022Article
- Evolution of a novel cell type in Dictyostelia required gene duplication of a cudA-like transcription factor.Current biology : CB · 2022Article
- Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators.Small GTPases · 2022Article
- Novel RNAseq-Informed Cell-type Markers and Their Regulation Alter Paradigms ofFrontiers in cell and developmental biology · 2022Article
- Phylogeny-wide analysis of G-protein coupled receptors in social amoebas and implications for the evolution of multicellularity.Open research Europe · 2022Article
- Article
- Transcriptional milestones inGenome research · 2021Article
- Review
- From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Abundantly expressed class of noncoding RNAs conserved through the multicellular evolution of dictyostelid social amoebas.Genome research · 2021Article
- The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy.Autophagy · 2021Article
- Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum.Genome biology and evolution · 2020Article
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7 authors.
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Abstract
The evolution of multicellularity enabled specialization of cells, but required novel signalling mechanisms for regulating cell differentiation. Early multicellular organisms are mostly extinct and the origins of these mechanisms are unknown. Here using comparative genome and transcriptome analysis across eight uni- and multicellular amoebozoan genomes, we find that 80% of proteins essential for the development of multicellular Dictyostelia are already present in their unicellular relatives. This set is enriched in cytosolic and nuclear proteins, and protein kinases. The remaining 20%, unique to Dictyostelia, mostly consists of extracellularly exposed and secreted proteins, with roles in sensing and recognition, while several genes for synthesis of signals that induce cell-type specialization were acquired by lateral gene transfer. Across Dictyostelia, changes in gene expression correspond more strongly with phenotypic innovation than changes in protein functional domains. We conclude that the transition to multicellularity required novel signals and sensors rather than novel signal processing mechanisms.
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