ArticleInternational journal of oral science2016
Human enamel thickness and ENAM polymorphism.
Article in International journal of oral science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Human Digestive Physiology and Evolutionary Diet: A Metabolomic Perspective on Carnivorous and Scavenger Adaptations.Metabolites · 2025Review
- Assessing Enamel Thickness to Estimate Interproximal Reduction: A CBCT-Based Study.Clinical and experimental dental research · 2025Article
- Article
- The Influence of demographic variables on the prevalence and severity of tooth wear in a Trinidadian population.Frontiers in oral health · 2025Article
- Population Structure and Selection Signatures in Chinese Indigenous Zhaotong Pigs Revealed by Whole-Genome Resequencing.Animals : an open access journal from MDPI · 2024Article
- Enam expression is regulated by Msx2.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Spatial analysis of polarimetric images to enhance near-surface sampling sensitivity: feasibility in demineralized teeth and other tissue-like media.Journal of biomedical optics · 2023Article
- Article
- Parity, dental caries and implications for maternal depletion syndrome in northern Nigerian Hausa women.PloS one · 2023Article
- Molecular Subtyping Based on Cuproptosis-Related Genes and Characterization of Tumor Microenvironment Infiltration in Kidney Renal Clear Cell Carcinoma.Frontiers in oncology · 2022Article
- Odontogenesis-related candidate genes involved in variations of permanent teeth size.Clinical oral investigations · 2021Article
- Detection of Dental Caries' and Dermatoglyphics' Association with Relative Enamel Thickness Using CBCT Images in Saudi Subpopulation: A Novel Approach.BioMed research international · 2021Article
- Evaluation of temperature rise in the pulp during various IPR techniques-an in vivo study.Progress in orthodontics · 2020Article
- ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations.International journal of environmental research and public health · 2020Article
- A methodology for evaluating tooth wear monitoring using timed automata modelling.Journal of oral rehabilitation · 2020Article
- MutantPeerJ · 2020Article
- Modeling enamel matrix secretion in mammalian teeth.PLoS computational biology · 2019Article
- Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children.Clinical oral investigations · 2018Article
- Variation in Enamel Formation Genes Influences Enamel DemineralizationFrontiers in physiology · 2017Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The tooth enamel development gene, enamelin (ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism (SNP) C14625T (rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status, controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel. Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner (P=0.040) when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.