ArticleBioinformatics (Oxford, England)2016
Estimating and testing high-dimensional mediation effects in epigenetic studies.
Article in Bioinformatics (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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Who cites it
114 citing papers in PubMed.
- Doubly robust evaluation of high-dimensional surrogate markers.Biostatistics (Oxford, England) · 2023Trial
- The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial.Genome medicine · 2022Trial
- High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.Nature communications · 2021Trial
- Differential DNA methylation in blood as potential mediator of the association between ambient PMMolecular psychiatry · 2026Article
- Deconfounded-Debiased Estimation and Inference for High-Dimensional Mediation Analysis With Pervasive Hidden Confounders.Statistics in medicine · 2026Article
- Gene set mediation analysis in high-dimensional epigenetic studies.Briefings in bioinformatics · 2026Article
- Blood metabolomic signatures linking air pollution to lung cancer in the Cancer Prevention Studies.Nature communications · 2026Article
- Proteomic Mediators Linking Autoimmune Diseases to Major Adverse Cardiovascular Events: Insights from the UK Biobank.Proteomes · 2026Article
- Sparse CCA-based mediation analysis with high-dimensional exposures and mediators.Bioinformatics (Oxford, England) · 2026Article
- Metabolites and proteins may mediate the relationship between diet quality and insulin sensitivity in young adult cohort.Journal of diabetes and metabolic disorders · 2026Article
- A multi-omics framework for survival mediation analysis of high-dimensional proteogenomic data.PLoS computational biology · 2026Article
- Bayesian Image Mediation Analysis.Journal of the American Statistical Association · 2026Article
- ESPLSM: An Efficient and Interpretable Mediation Analysis Framework Using Sparse Envelopes.Statistics in medicine · 2026Article
- Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026Article
- Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset.Annals of neurology · 2026Article
- Evaluating Methods for High-Dimensional Mediation in Metabolomics Data.Environmental science & technology · 2026Article
- BHMnet: Bayesian high-dimensional mediation analysis with network information integration for correlated mediators.Briefings in bioinformatics · 2026Article
- Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization.JACC. Advances · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- Microbiome mediation analysis: methods, assumptions, and practical considerations.Frontiers in cellular and infection microbiology · 2026Review
54 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
Abstract
motivationHigh-dimensional DNA methylation markers may mediate pathways linking environmental exposures with health outcomes. However, there is a lack of analytical methods to identify significant mediators for high-dimensional mediation analysis.
resultsBased on sure independent screening and minimax concave penalty techniques, we use a joint significance test for mediation effect. We demonstrate its practical performance using Monte Carlo simulation studies and apply this method to investigate the extent to which DNA methylation markers mediate the causal pathway from smoking to reduced lung function in the Normative Aging Study. We identify 2 CpGs with significant mediation effects. AVAILABILITY AND IMPLEMENTATION: R package, source code, and simulation study are available at https://github.com/YinanZheng/HIMA CONTACT: lei.liu@northwestern.edu.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.