Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.
Lyndsay A Staley, Mark T W Ebbert, Sheradyn Parker, Matthew Bailey, Alzheimer’s Disease Neuroimaging Initiative, Perry G Ridge, Alison M Goate, John S K Kauwe
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 26% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 1 institution in 1 country.
Lyndsay A StaleyDepartment of Biology, Brigham Young University, Provo, UT, 84602, USA.
Mark T W EbbertDepartment of Biology, Brigham Young University, Provo, UT, 84602, USA.
Sheradyn ParkerDepartment of Biology, Brigham Young University, Provo, UT, 84602, USA.
Matthew BaileyBiology and Biomedical Sciences, Washington University, St. Louis, MO, 63110, USA.
Alzheimer’s Disease Neuroimaging Initiative
Perry G RidgeDepartment of Biology, Brigham Young University, Provo, UT, 84602, USA.
Alison M GoateDepartment of Neuroscience Icahn School of Medicine, New York, NY, 10029, USA.
John S K KauweDepartment of Biology, Brigham Young University, Provo, UT, 84602, USA. Kauwe@byu.edu.
Brigham Young University · US
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Collaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4M
Research Supplements to Promote Diversity in Health-Related ResearchR01AG042611 · NIA · BRIGHAM YOUNG UNIVERSITY · PI KAUWE, JOHN SAI KEONG · 2012 to 2017
$1.5M
Medical Research Council 503480Medical Research Council G0300429Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2NHLBI NIH HHS R01 HL105756NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG042611NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886Wellcome TrustWellcome Trust 082604/2/07/ZWellcome Trust GR082604MA
6 · The paper itself
Abstract
backgroundProlactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF).
methodsIn this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets.
resultsWe identified 12 SNPs associated with increased prolactin levels in both biological fluids.
conclusionsOur efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.
Indexed as
Polymorphism, Single NucleotideAdultAgedAged, 80 and overAlzheimer DiseaseBiomarkersCalcium-Calmodulin-Dependent Protein KinasesFemaleGene FrequencyGenome-Wide Association StudyGenotypeHumansIntracellular Signaling Peptides and ProteinsLinear ModelsLinkage DisequilibriumMeta-Analysis as TopicBiomarkersCalcium-Calmodulin-Dependent Protein KinasesIntracellular Signaling Peptides and ProteinsProlactinSULF1 protein, humanSulfotransferasesTRIB2 protein, humanAssociationCSFGeneticsPlasmaProlactin
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. · full record | OpenQuestion