ReviewThe Journal of physiology2016
Parasympathetic innervation of vertebrobasilar arteries: is this a potential clinical target?
Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Article
- Article
- Real-time in vivo imaging of rodent brain response to hypoperfusion enabled by remotely controlled elastomeric micro-balloons.bioRxiv : the preprint server for biology · 2025Article
- Association of carotid artery stenosis with cerebral artery signal intensity gradient on time-of-flight magnetic resonance angiography.Frontiers in neurology · 2025Article
- Posterior reversible enzephalopathie syndrome (PRES) following vestibular schwannoma surgery - Case report and review of the current theories on pathophysiology of PRES.Brain & spine · 2025Review
- Revising the Interpretation of Transcranial Doppler Ultrasound Examinations in Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2024Article
- Comparable dynamic cerebral autoregulation and neurovascular coupling of the posterior cerebral artery between healthy men and women.CNS neuroscience & therapeutics · 2024Article
- Supratentorial hemangioblastoma: correlation between phenotype, gender and vascular territory affected.Neurosurgical review · 2023Article
- Anticipatory central command on standing decreases cerebral blood velocity causing hypocapnia in hyperpneic postural tachycardia syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms.Biomedicines · 2023Review
- Myography of isolated blood vessels: Considerations for experimental design and combination with supplementary techniques.Frontiers in physiology · 2023Review
- Neural control of cerebral blood flow: scientific basis of scalp acupuncture in treating brain diseases.Frontiers in neuroscience · 2023Review
- Article
- Mechanisms of Transcranial Doppler Ultrasound phenotypes in paediatric cerebral malaria remain elusive.Malaria journal · 2022Observational
- Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats.Physiological reports · 2021Article
- Spatiotemporal Dynamics of Cerebral Vascular Permeability in Type 2 Diabetes-Related Cerebral Microangiopathy.Frontiers in endocrinology · 2021Article
- Regulation of Blood Flow in the Cerebral Posterior Circulation by Parasympathetic Nerve Fibers: Physiological Background and Possible Clinical Implications in Patients With Vertebrobasilar Stroke.Frontiers in neurology · 2021Review
- Differentiating Dynamic Cerebral Autoregulation Across Vascular Territories.Frontiers in neurology · 2021Article
- Transcranial Doppler for Monitoring and Evaluation of Idiopathic Intracranial Hypertension.Journal of neurosciences in rural practice · 2020Article
- Effect of bilateral carotid occlusion on cerebral hemodynamics and perivascular innervation: An experimental rat model.The Journal of comparative neurology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This review aims to summarise the contemporary evidence for the presence and function of the parasympathetic innervation of the cerebral circulation with emphasis on the vertebral and basilar arteries (the posterior cerebral circulation). We consider whether the parasympathetic innervation of blood vessels could be used as a means to increase cerebral blood flow. This may have clinical implications for pathologies associated with cerebral hypoperfusion such as stroke, dementia and hypertension. Relative to the anterior cerebral circulation little is known of the origins and neurochemical phenotypes of the parasympathetic innervation of the vertebrobasilar arteries. These vessels normally provide blood flow to the brainstem and cerebellum but can, via the Circle of Willis upon stenosis of the internal carotid arteries, supply blood to the anterior cerebral circulation too. We review the multiple types of parasympathetic fibres and their distinct transmitter mechanisms and how these vary with age, disease and species. We highlight the importance of parasympathetic fibres for mediating the vasodilatory response to sympathetic activation. Current trials are investigating the possibility of electrically stimulating the postganglionic parasympathetic ganglia to improve cerebal blood flow to reduce the penumbra following stroke. We conclude that although there are substantial gaps in our understanding of the origins of parasympathetic innervation of the vertebrobasilar arteries, activation of this system under some conditions might bring therapeutic benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.