Evidence map›Paper›PMID 27356974›Full record

ArticlePlant physiology2016

A Stilbenoid-Specific Prenyltransferase Utilizes Dimethylallyl Pyrophosphate from the Plastidic Terpenoid Pathway.

Tianhong Yang, Lingling Fang, Agnes M Rimando, Victor Sobolev, Keithanne Mockaitis, Fabricio Medina-Bolivar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Synthesis ofRSC advances · 2022
    Article
  6. Stilbenoids: A Natural Arsenal against Bacterial Pathogens.Antibiotics (Basel, Switzerland) · 2020
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tianhong YangArkansas Biosciences Institute (T.Y., L.F., F.M.-B.), Molecular Biosciences Graduate Program (T.Y.), and Department of Biological Sciences (L.F., F.M.-B.), Arkansas State University, Jonesboro, Arkansas 72467;Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, Mississippi 38677 (A.M.R.);National Peanut Research Laboratory, Dawson, Georgia 39842 (V.S.); andPervasive Technology Institute and Department of Biology, Indiana University, Bloomington, Indiana 47408 (K.M.).ORCID 0000-0002-3873-0602
Lingling FangArkansas Biosciences Institute (T.Y., L.F., F.M.-B.), Molecular Biosciences Graduate Program (T.Y.), and Department of Biological Sciences (L.F., F.M.-B.), Arkansas State University, Jonesboro, Arkansas 72467;Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, Mississippi 38677 (A.M.R.);National Peanut Research Laboratory, Dawson, Georgia 39842 (V.S.); andPervasive Technology Institute and Department of Biology, Indiana University, Bloomington, Indiana 47408 (K.M.).ORCID 0000-0003-2938-9155
Agnes M RimandoArkansas Biosciences Institute (T.Y., L.F., F.M.-B.), Molecular Biosciences Graduate Program (T.Y.), and Department of Biological Sciences (L.F., F.M.-B.), Arkansas State University, Jonesboro, Arkansas 72467;Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, Mississippi 38677 (A.M.R.);National Peanut Research Laboratory, Dawson, Georgia 39842 (V.S.); andPervasive Technology Institute and Department of Biology, Indiana University, Bloomington, Indiana 47408 (K.M.).ORCID 0000-0001-8229-8506
Victor SobolevArkansas Biosciences Institute (T.Y., L.F., F.M.-B.), Molecular Biosciences Graduate Program (T.Y.), and Department of Biological Sciences (L.F., F.M.-B.), Arkansas State University, Jonesboro, Arkansas 72467;Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, Mississippi 38677 (A.M.R.);National Peanut Research Laboratory, Dawson, Georgia 39842 (V.S.); andPervasive Technology Institute and Department of Biology, Indiana University, Bloomington, Indiana 47408 (K.M.).ORCID 0000-0001-5352-9539
Keithanne MockaitisArkansas Biosciences Institute (T.Y., L.F., F.M.-B.), Molecular Biosciences Graduate Program (T.Y.), and Department of Biological Sciences (L.F., F.M.-B.), Arkansas State University, Jonesboro, Arkansas 72467;Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, Mississippi 38677 (A.M.R.);National Peanut Research Laboratory, Dawson, Georgia 39842 (V.S.); andPervasive Technology Institute and Department of Biology, Indiana University, Bloomington, Indiana 47408 (K.M.).ORCID 0000-0001-6123-8424
Fabricio Medina-BolivarArkansas Biosciences Institute (T.Y., L.F., F.M.-B.), Molecular Biosciences Graduate Program (T.Y.), and Department of Biological Sciences (L.F., F.M.-B.), Arkansas State University, Jonesboro, Arkansas 72467;Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, Mississippi 38677 (A.M.R.);National Peanut Research Laboratory, Dawson, Georgia 39842 (V.S.); andPervasive Technology Institute and Department of Biology, Indiana University, Bloomington, Indiana 47408 (K.M.) fmedinabolivar@astate.edu.ORCID 0000-0002-6237-1232
Arkansas State University · USIndiana University Bloomington · USAgricultural Research Service · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenylated stilbenoids synthesized in some legumes exhibit plant pathogen defense properties and pharmacological activities with potential benefits to human health. Despite their importance, the biosynthetic pathways of these compounds remain to be elucidated. Peanut (Arachis hypogaea) hairy root cultures produce a diverse array of prenylated stilbenoids upon treatment with elicitors. Using metabolic inhibitors of the plastidic and cytosolic isoprenoid biosynthetic pathways, we demonstrated that the prenyl moiety on the prenylated stilbenoids derives from a plastidic pathway. We further characterized, to our knowledge for the first time, a membrane-bound stilbenoid-specific prenyltransferase activity from the microsomal fraction of peanut hairy roots. This microsomal fraction-derived resveratrol 4-dimethylallyl transferase utilizes 3,3-dimethylallyl pyrophosphate as a prenyl donor and prenylates resveratrol to form arachidin-2. It also prenylates pinosylvin to chiricanine A and piceatannol to arachidin-5, a prenylated stilbenoid identified, to our knowledge, for the first time in this study. This prenyltransferase exhibits strict substrate specificity for stilbenoids and does not prenylate flavanone, flavone, or isoflavone backbones, even though it shares several common features with flavonoid-specific prenyltransferases.

Indexed as

ArachisDimethylallyltranstransferaseHemiterpenesOrganophosphorus CompoundsPhytoalexinsPlant ProteinsPlant RootsPlastidsPrenylationResveratrolSeedsStilbenesSubstrate SpecificityTerpenes3,3',4,5'-tetrahydroxystilbene3,3-dimethylallyl pyrophosphateDimethylallyltranstransferaseHemiterpenesOrganophosphorus CompoundsPhytoalexinspinosylvinPlant ProteinsResveratrolStilbenesTerpenes

Identifiers

PMID27356974
PMCPMC4972285
OpenAlexW2497871723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.