Observational studyNeurosciences (Riyadh, Saudi Arabia)2016
Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan.
Observational study in Neurosciences (Riyadh, Saudi Arabia), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Utilization of Anti-Seizure Medication (ASMS) and Seizure Control in Pediatric Epilepsy: A Retrospective Cross-Sectional Study in Oman.Healthcare (Basel, Switzerland) · 2026Article
- Treatment Response in Pediatric Patients with Status Epilepticus: A Retrospective Observational Study from Saudi Arabia.Journal of clinical medicine · 2025Article
- Frequency of antiepileptic drugs and response change in pediatric patients receiving 2 or more antiepileptic drugs.Neurosciences (Riyadh, Saudi Arabia) · 2020Observational
- Pharmacokinetics and Pharmacogenetics of Carbamazepine in Children.European journal of drug metabolism and pharmacokinetics · 2017Review
- Effect of early postnatal exposure to valproate on neurobehavioral development and regional BDNF expression in two strains of mice.Epilepsy & behavior : E&B · 2017Article
- Anti-epileptic drug utilisation in paediatrics: a systematic review.BMJ paediatrics open · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine prescribing patterns of antiepileptic drugs (AEDs) in pediatric patients with confirmed diagnosis of epilepsy, and to provide knowledge of general practice of physicians.
methodsThe study was a multi-center crosssectional observational study, in specialized clinics for management of epilepsy in north, central and south Jordan. This study was conducted from January 2014 to July 2014. These were 3 from university tertiary care hospitals and 4 from governmental tertiary care hospitals.
resultsA total of 694 pediatric patients were included. Monotherapy AED use had the highest frequency 465 (67.0%), followed by dual therapy 162 (23.3%). The frequency of monotherapy in university hospitals was lower than governmental hospitals (p<0.05); however, Polytherapy was more frequent in younger children. Two old AEDs were most frequently prescribed as a monotherapy; Valproic acid 235 (50.5%) and carbamazepine 155 (33.3%). The most common combination in dual therapy was valproic acid with carbamazepine 28 (17.3%). The second most common combinations were carbamazepine with levetiracetam 21 (13.0%) or valproic acid with levetiracetam 20 (12.3%).
conclusionOlder AED remain first line drugs for use in both monotherapy and combination therapy for epileptic disorders. Polytherapy is associated with younger kids and being treated in a university hospital.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.