ArticleScientific reports2016
Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of public RNA-Seq data identifies conserved stress responses in rainbow trout.BMC genomics · 2025Pooled it
- Orthology-Aware Reanalysis of Replicated Public Transcriptomes Identifies Shared and Context-Dependent Low-Temperature Responses in Teleost Fishes.Marine biotechnology (New York, N.Y.) · 2026Article
- Effects of Hydrogen-Rich Water on Juvenile Largemouth Bass (Antioxidants (Basel, Switzerland) · 2026Article
- Integrative epigenomic and transcriptomic profiling reveals organ-specific and coordinated cold stress responses in the brain and gill of Nile tilapia.Stress biology · 2026Article
- Genome-Wide Identification of the Transient Receptor Potential Channel Family in Nile Tilapia and Expression Analysis in Response to Cold Stress.Animals : an open access journal from MDPI · 2025Article
- Article
- RNA-Seq Revealed the Effects of Cold Stress on Different Brain Regions ofAnimals : an open access journal from MDPI · 2025Article
- Seasonal transcriptome profile across three different tissues of the Andean Killifish Orestias ascotanensis.Scientific data · 2025Article
- Chromatin dynamics and transcriptional regulation of heat stress in an ectothermic fish.Proceedings. Biological sciences · 2025Article
- Integrated Analysis of Transcriptome and Metabolome in the Brain After Cold Stress of Red Tilapia During Overwintering.International journal of molecular sciences · 2024Article
- Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish.Zoological research · 2024Article
- Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage.Nature communications · 2024Article
- Effects of different temperatures on Leiocassis longirostris gill structure and intestinal microbial composition.Scientific reports · 2024Article
- Comparative Transcriptome Analyses Provide New Insights into the Evolution of Divergent Thermal Resistance in Two Eel Gobies.Current issues in molecular biology · 2023Article
- Article
- Influence of Docosahexaenoic and Eicosapentaenoic Acid Ratio and Temperature on the Growth Performance, Fatty Acid Profile, and Liver Morphology of Dusky Grouper (Animals : an open access journal from MDPI · 2023Article
- Article
- PPAR Signaling Maintains Metabolic Homeostasis under Hypothermia in Freshwater Drum (Metabolites · 2023Article
- Article
- Understanding the Function and Mechanism of Zebrafish Tmem39b in Regulating Cold Resistance.International journal of molecular sciences · 2022Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Transcriptional plasticity is a major driver of phenotypic differences between species. The lower temperature limit (LTL), namely the lower end of survival temperature, is an important trait delimiting the geographical distribution of a species, however, the genetic mechanisms are poorly understood. We investigated the inter-species transcriptional diversification in cold responses between zebrafish Danio rerio and tilapia Oreochromis niloticus, which were reared at a common temperature (28 °C) but have distinct LTLs. We identified significant expressional divergence between the two species in the orthologous genes from gills when the temperature cooled to the LTL of tilapia (8 °C). Five KEGG pathways were found sequentially over-represented in the zebrafish/tilapia divergently expressed genes in the duration (12 hour) of 8 °C exposure, forming a signaling cascade from metabolic regulation to apoptosis via FoxO signaling. Consistently, we found differential progression of apoptosis in the gills of the two species in which zebrafish manifested a delayed and milder apoptotic phenotype than tilapia, corresponding with a lower LTL of zebrafish. We identified diverged expression in 25 apoptosis-related transcription factors between the two species which forms an interacting network with diverged factors involving the FoxO signaling and metabolic regulation. We propose a genetic network which regulates LTL in fishes.
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