Evidence map›Paper›PMID 27356266›Full record

ArticleAnalytical chemistry2016

Sensing Glucose in Urine and Serum and Hydrogen Peroxide in Living Cells by Use of a Novel Boronate Nanoprobe Based on Surface-Enhanced Raman Spectroscopy.

Xin Gu, Hao Wang, Zachary D Schultz, Jon P Camden

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Chemical science · 2024
    Article
  5. Article
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  7. Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  8. Article
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  14. Article
  15. A Biomimetic Plasmonic Nanoreactor for Reliable Metabolite Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xin GuDepartment of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States.
Hao WangDepartment of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States.
Zachary D SchultzDepartment of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States.
Jon P CamdenDepartment of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States.
University of Notre Dame · US

Funding

Targeted TERS Investigations of Ligand-Receptor BindingR01GM109988 · NIGMS · UNIVERSITY OF NOTRE DAME · PI SCHULTZ, ZACHARY · 2015 to 2024
$3.2M
NIGMS NIH HHS R01 GM109988
6 · The paper itself

Abstract

Hydrogen peroxide (H2O2) is known as a key molecule in a variety of biological processes, as well as a crucial byproduct in many enzymatic reactions. Therefore, being able to selectively and sensitively detect H2O2 is not only important in monitoring, estimating, and decoding H2O2 relevant physiological pathways but also very helpful in developing enzymatic-based biosensors for other analytes of interest. Herein, we report a plasmonic probe for H2O2 based on 3-mercaptophenylboronic acid (3-MPBA) modified gold nanoparticles (AuNPs) which is coupled with surface-enhanced Raman scattering (SERS) to yield a limit of detection (LOD) of 70 nM. Our probe quantifies both exogenous and endogenous H2O2 levels in living cells and can further be coupled with glucose oxidase (GOx) to achieve quantitative and selective detection of glucose in artificial urine and human serum.

Indexed as

Biosensing TechniquesBlood GlucoseBoronic AcidsCell Line, TumorGlucose OxidaseGoldHumansHydrogen PeroxideLimit of DetectionMetal NanoparticlesSpectrum Analysis, RamanBlood GlucoseBoronic AcidsGlucose OxidaseGoldHydrogen Peroxide

Identifiers

PMID27356266
PMCPMC4955533
OpenAlexW2472811347

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.