Trial reportObesity (Silver Spring, Md.)2016
No evidence for metabolic adaptation in thermic effect of food by dietary protein.
Trial report in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Changes in 24-h energy expenditure, substrate oxidation, and body composition following resistance exercise and a high protein diet via whey protein supplementation in healthy older men.Physiological reports · 2022Trial
- Effect of Overeating Dietary Protein at Different Levels on Circulating Lipids and Liver Lipid: The PROOF Study.Nutrients · 2020Trial
- Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study.Obesity (Silver Spring, Md.) · 2018Trial
- Day-to-day variability in resting metabolic rate in strength athletes.Journal of the International Society of Sports Nutrition · 2026Article
- Associations of higher protein intake with diet quality and diabetes-related metabolic health indicators in Korean adults without diabetes: analysis of Korean National Health and Nutrition Examination Survey (KNHANES) 2019-2021.Nutrition research and practice · 2026Article
- Plant-based caloric restriction diets versus conventional calorie-restricted diets for weight loss and metabolic health in obese adults: a 12-week randomized, open-label, non-inferiority trial.Frontiers in nutrition · 2026Article
- Using Metabolic Testing to Personalize Behavioral Obesity Treatment.Obesity science & practice · 2025Article
- Review
- Metabolic impact of feeding prior to a 60-min bout of moderate-intensity exercise in females in a fasted state.Frontiers in sports and active living · 2022Article
- A high-protein total diet replacement increases energy expenditure and leads to negative fat balance in healthy, normal-weight adults.The American journal of clinical nutrition · 2021Article
- Dietary protein intake and obesity-associated cardiometabolic function.Current opinion in clinical nutrition and metabolic care · 2020Review
- In the Footsteps of Wilbur Olin Atwater: The Atwater Lecture for 2019.Advances in nutrition (Bethesda, Md.) · 2020Article
- A word of caution against excessive protein intake.Nature reviews. Endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveDetermine whether prolonged consumption of high- or low-protein diets modifies the thermogenic response to a standard meal.
methodsTwenty-four healthy individuals were randomized to overfeeding diets containing low (5%, n = 8), normal (15%, n = 9), or high (25%, n = 7) protein for 56 days while inpatients. The thermic effect of food (TEF) was measured over 4 h by indirect calorimetry following a standard meal (20% of energy, 20% protein) or a meal that matched the study diet ("study meal").
resultsAs expected, the TEF following the study meal (i.e., either low, normal, or high protein content) was significantly associated with dietary protein (P = 0.007), and the TEF was significantly increased in the high-protein diet (15.4%) versus the normal-protein (5.6%) and low-protein diets (6.4%) (P = 0.05 and P = 0.03, respectively). However, returning to a standard meal (20% protein) after 42 days of overfeeding the study diets, the TEF response did not differ from baseline between groups or within subjects regardless of the prolonged intake of the habitual study diet (high protein: P = 0.32, low protein: P = 0.11, normal protein: P = 0.79).
conclusionsTEF is related to acute dietary protein intake but not altered by prolonged intake of high-energy diets with high or low protein content.
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Registered trials
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