ArticlePloS one2016
Transcriptome Profiling Reveals the Antitumor Mechanism of Polysaccharide from Marine Algae Gracilariopsis lemaneiformis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Natural polysaccharides as multifunctional anti-cancer agents: structure-activity relationships, mechanisms of action, and therapeutic potential.Frontiers in immunology · 2026Review
- A Comprehensive, Analytical Narrative Review of Polysaccharides from the Red SeaweedNutrients · 2025Review
- Bioactive Polysaccharides fromFoods (Basel, Switzerland) · 2024Review
- Analysis of Hyperosmotic Tolerance Mechanisms inGenes · 2024Article
- Breeding of New Strains of Gracilariopsis lemaneiformis with High Agar Content by ARTP Mutagenesis and High Osmotic Pressure Screening.Marine biotechnology (New York, N.Y.) · 2023Article
- Ploidy Identification by Flow Cytometry and Application of the Method to Characterize Seasonal Ploidy Variation of Wild Populations of the Red Alga Gracilariopsis lemaneiformis.Marine biotechnology (New York, N.Y.) · 2022Article
- Insights on preparation, structure and activities ofFood chemistry: X · 2021Article
- Anti-tumor effect of polysaccharide from Pleurotus ostreatus on H22 mouse Hepatoma ascites in-vivo and hepatocellular carcinoma in-vitro model.AMB Express · 2021Article
- Effects of Different Molecular Weight Polysaccharides FromFrontiers in pharmacology · 2021Article
- Alterations in the CaExploration of targeted anti-tumor therapy · 2021Article
- Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review.Molecules (Basel, Switzerland) · 2020Review
- Advances in exploring the therapeutic potential of marine natural products.Pharmacological research · 2019Review
- Anti-Tumor Activity of Cembranoid-Type Diterpenes Isolated from Nicotiana tabacum L.Biomolecules · 2019Article
- Recent Advances in Marine Algae Polysaccharides: Isolation, Structure, and Activities.Marine drugs · 2017Review
- Cytological Assessments and Transcriptome Profiling Demonstrate that Evodiamine Inhibits Growth and Induces Apoptosis in a Renal Carcinoma Cell Line.Scientific reports · 2017Article
- Characterization and Potential Antitumor Activity of Polysaccharide from Gracilariopsis lemaneiformis.Marine drugs · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seaweed is one of the important biomass producers and possesses active metabolites with potential therapeutic effects against tumors. The red alga Gracilariopsis lemaneiformis (Gp. lemaneiformis) possesses antitumor activity, and the polysaccharide of Gp. lemaneiformis (PGL) has been demonstrated to be an ingredient with marked anticancer activity. However, the anticancer mechanism of PGL remains to be elucidated. In this study, we analyzed the inhibitory effect of PGL on the cell growth of 3 human cancer cell lines and found that PGL inhibited cell proliferation, reduced cell viability, and altered cell morphology in a time- and concentration-dependent manner. Our transcriptome analysis indicates that PGL can regulate the expression of 758 genes, which are involved in apoptosis, the cell cycle, nuclear division, and cell death. Furthermore, we demonstrated that PGL induced apoptosis and cell cycle arrest and modulated the expression of related genes in the A549 cell line. Our work provides a framework to understand the effects of PGL on cancer cells, and can serve as a resource for delineating the antitumor mechanisms of Gp. lemaneiformis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.