ArticleOncoTargets and therapy2016
Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice.
Article in OncoTargets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.The Journal of veterinary medical science · 2025Article
- Immune dysregulation in ulcerative colitis: pathogenic mechanisms and therapeutic strategies of traditional Chinese medicine.Frontiers in cell and developmental biology · 2025Review
- Spore Oil enhances the effect of cyclophosphamide inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Diselenide Covalent Allosteric Inhibitors of Glutaminase with StrongACS medicinal chemistry letters · 2023Article
- Structural characterization and immunomodulatory activity of a novel polysaccharide fromFrontiers in pharmacology · 2023Article
- [Therapeutic effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Article
- The Antiviral Effect of Panax Notoginseng Polysaccharides by Inhibiting PRV Adsorption and Replication In Vitro.Molecules (Basel, Switzerland) · 2022Article
- Research progress of ginseng in the treatment of gastrointestinal cancers.Frontiers in pharmacology · 2022Review
- A review of the immunomodulatory activities of polysaccharides isolated fromJournal of ginseng research · 2022Review
- Comparisons of Isolation Methods, Structural Features, and Bioactivities of the Polysaccharides from Three Common Panax Species: A Review of Recent Progress.Molecules (Basel, Switzerland) · 2021Review
- Dual role of immunomodulation by crude polysaccharide from okra against carcinogenic liver injury in mice.Heliyon · 2021Article
- Fermentation of Panax notoginseng root extract polysaccharides attenuates oxidative stress and promotes type I procollagen synthesis in human dermal fibroblast cells.BMC complementary medicine and therapies · 2021Article
- Neutral polysaccharide from Panax notoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22-bearing mice.BMC cancer · 2021Article
- Article
- Biological Effects of Korean Red Ginseng Polysaccharides in Aged Rat Using Global Proteomic Approach.Molecules (Basel, Switzerland) · 2020Article
- Scutellaria barbata polysaccharides inhibit tumor growth and affect the serum proteomic profiling of hepatoma H22‑bearing mice.Molecular medicine reports · 2019Article
- Kidney-Type Glutaminase Inhibitor Hexylselen Selectively Kills Cancer Cells via a Three-Pronged Mechanism.ACS pharmacology & translational science · 2019Article
- Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases.Aging and disease · 2017Review
- Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolysaccharides from various sources are being considered potential sources for the treatment of liver cancer. The aim of this study was to investigate the impact of polysaccharide isolated from Panax notoginseng (PPN) on the proliferation of H22 liver cancer cells and the survival of the tumor-bearing mice transplanted with H22 cells. MATERIALS AND
methodsPolysaccharide from PPN was added to the culture medium of mouse hepatoma H22 cells at different doses. Cell proliferation was assayed with a standard MTT assay. Survival rates of tumor-bearing mice were recorded. Peripheral blood lymphocytes were assayed by flow cytometry. Serum interleukin-2 levels in peripheral blood were measured by enzyme-linked immunosorbent assay.
resultsPolysaccharide from PPN inhibited the growth of H22 cells and significantly prolonged the survival of tumor-bearing mice. The increase in activated CD4(+) T-cells and the elevation of serum interleukin-2 may contribute to the antitumor activity of PPN.
conclusionPPN has potential antitumor activity for the treatment of liver cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.