Evidence map›Paper›PMID 27354787›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2016

Depression symptoms reduce physical activity in COPD patients: a prospective multicenter study.

Iván Dueñas-Espín, Heleen Demeyer, Elena Gimeno-Santos, Michael I Polkey, Nicholas S Hopkinson, Roberto A Rabinovich, Fabienne Dobbels, Niklas Karlsson, Thierry Troosters, Judith Garcia-Aymerich

Abstract readMulticenter Study
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Gait differences between COPD and healthy controls: systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Pooled it
  3. Depression and Objectively Measured Physical Activity: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
    Pooled it
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  8. Comparing the determinants of health perception and quality of life over time in heart and lung diseases: structural equation modeling.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  9. Mind over lungs: the impact of coping strategies on pulmonary rehabilitation outcomes.European journal of physical and rehabilitation medicine · 2026
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  14. Review
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  19. Physical Activity, Depression and Quality of Life in COPD - Results from the CLARA II Study.International journal of chronic obstructive pulmonary disease · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iván Dueñas-EspínISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBEREpidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Secretaría Nacional de Educación Superior, Ciencia, Tecnología e Innovación del Ecuador (SENESCYT), Quito, Ecuador; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Heleen DemeyerDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Elena Gimeno-SantosISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBEREpidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Michael I PolkeyNIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.
Nicholas S HopkinsonNIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.
Roberto A RabinovichELEGI Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Fabienne DobbelsDepartment of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven, Leuven, Belgium.
Niklas KarlssonHealth Economics and Outcomes Research, AstraZeneca R&D, Mölndal, Sweden.
Thierry TroostersDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgium; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Judith Garcia-AymerichISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBEREpidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of anxiety and depression in the physical activity (PA) of patients with COPD is controversial. We prospectively assessed the effect of symptoms of anxiety and depression on PA in COPD patients.

methodsWe evaluated anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), PA (Dynaport(®) accelerometer), and other relevant characteristics in 220 COPD patients from five European countries at baseline and at 6 and 12 months of follow-up. HADS score was categorized as: no symptoms (score 0-7), suggested (8-10), and probable (>11) anxiety or depression. We estimated the association between anxiety and depression at t (baseline and 6 months) and PA at t+1 (6 and 12 months) using regression models with a repeated measures approach.

resultsPatients had a mean (standard deviation) age of 67 (8) years, forced expiratory volume in 1 second 57 (20)% predicted. At baseline, the prevalence of probable anxiety and depression was 10% and 5%, respectively. In multivariable models adjusted by confounders and previous PA, patients performed 81 fewer steps/day (95% confidence interval, -149 to -12, P=0.02) per extra point in HADS-depression score. HADS-anxiety symptoms were not associated with PA.

conclusionIn COPD patients, symptoms of depression are prospectively associated with a measurable reduction in PA 6 months later.

Indexed as

ExerciseActigraphyAgedAnxietyDepressionEuropeFemaleForced Expiratory VolumeHumansLongitudinal StudiesLungMaleMiddle AgedPrevalenceProspective StudiesPulmonary Disease, Chronic ObstructiveanxietyCOPDdepressionHADSphysical activityprospective study

Identifiers

PMID27354787
PMCPMC4910613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.