Observational studyInternational journal of chronic obstructive pulmonary disease2016
Impact of mild exacerbation on COPD symptoms in a Japanese cohort.
Observational study in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diffusing capacity in chronic obstructive pulmonary disease assessment: A meta-analysis.Chronic respiratory diseasePooled it
- Determinants of high chronic obstructive pulmonary disease assessment test scores according to airflow limitation severity: a three-year prospective study.BMC pulmonary medicine · 2026Article
- Phenotypes of Exacerbations in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2025Review
- Clinical Characteristics and Frequency of Chronic Obstructive Pulmonary Disease Exacerbations in Korean Patients: Findings From the KOCOSS Cohort 2012-2021.Journal of Korean medical science · 2024Article
- Phenotypes, Etiotypes, and Endotypes of Exacerbations of Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Review
- Interaction of BMI and respiratory status in obstructive sleep apnea, a cross-sectional COPD study.NPJ primary care respiratory medicine · 2023Article
- Article
- Bacterial Species and Inflammatory Cell Variability in Respiratory Tracts of Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Multicentric Study.Infection and drug resistance · 2023Article
- Effect of timing of bronchodilator therapy initiation on exacerbations in patients with chronic obstructive pulmonary disease: a retrospective cohort study.Respiratory research · 2022Article
- Giving Voice to People - Experiences During Mild to Moderate Acute Exacerbations of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease.Respiration; international review of thoracic diseases · 2022Observational
- Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change.Scientific reports · 2021Observational
- Characteristics of Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension Assessed by Echocardiography in a Three-Year Observational Cohort Study.International journal of chronic obstructive pulmonary disease · 2020Observational
- Unreported and Overlooked: A Post Hoc Analysis of COPD Symptom-Related Attacks from the RISE Study.International journal of chronic obstructive pulmonary disease · 2020Article
- Impact of cataract on health-related quality of life in a longitudinal Japanese chronic obstructive pulmonary cohort.Chronic respiratory disease · 2018Observational
- Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients.BMC pulmonary medicine · 2018Observational
- The Short-term Impact of Symptom-defined COPD Exacerbation Recovery on Health Status and Lung Function.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2018Article
- Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017Observational
- Understanding low COPD exacerbation rates in Japan: a review and comparison with other countries.International journal of chronic obstructive pulmonary diseaseReview
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with COPD might not report mild exacerbation. The frequency, risk factors, and impact of mild exacerbation on COPD status are unknown.
objectivesThe present study was performed to compare features between mild exacerbation and moderate or severe exacerbation in Japanese patients with COPD. PATIENTS AND
methodsAn observational COPD cohort was designed at Keio University and affiliated hospitals to prospectively investigate the management of COPD comorbidities. This study analyzes data only from patients with COPD who had completed annual examinations and questionnaires over a period of 2 years (n=311).
resultsAmong 59 patients with mild exacerbations during the first year, 32.2% also experienced only mild exacerbations in the second year. Among 60 patients with moderate or severe exacerbations during the first year, 40% also had the same severity of exacerbation during the second year. Findings of the COPD assessment test and the symptom component of the St George's Respiratory Questionnaire at steady state were worse in patients with mild exacerbations than in those who were exacerbation free during the 2-year study period, although the severity of the ratio of predicted forced expiratory volume in 1 second did not differ between them. Severe airflow limitation (the ratio of predicted forced expiratory volume in 1 second <50%) and experience of mild exacerbations independently advanced the likelihood of an elevated COPD assessment test score to ≥2 per year.
conclusionThe severity of COPD exacerbation seemed to be temporally stable over 2 years, and even mild exacerbations adversely impacted the health-related quality of life of patients with COPD.
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