ArticleInternational journal of chronic obstructive pulmonary disease2016
Lung perfusion and emphysema distribution affect the outcome of endobronchial valve therapy.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Regional ventilation-perfusion changes after endobronchial valve therapy assessed by single-photon emission computed tomography in adults with severe COPD.Scientific reports · 2026Article
- Endoscopic Lung Volume Reduction with Valves Improves Cardiovascular Adaptability and 6-MWT Performance in Severely Limited COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Article
- GOLD grade-specific characterization of COPD in the COSYCONET multi-center trial: comparison of semiquantitative MRI and quantitative CT.European radiology · 2025Article
- Role of quantitative planar lung perfusion scintigraphy and tomography in identifying target lobes in patients with emphysematous phenotype of advanced chronic obstructive pulmonary disease: a retrospective cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- First real-time imaging of bronchoscopic lung volume reduction by electrical impedance tomography.Respiratory research · 2024Article
- Impact of Bronchoscopic Lung Volume Reduction with Valves on the Pulmonary Gas Exchange.Journal of clinical medicine · 2024Article
- Head-to-Head Comparison of Dual-Source and Split-Beam Filter Multi-Energy CT versus SPECT/CT for Assessing Lobar Lung Perfusion in Emphysema.Radiology. Cardiothoracic imaging · 2023Article
- Clinical outcomes and quantitative CT analysis after bronchoscopic lung volume reduction using valves for advanced emphysema.Journal of thoracic disease · 2022Article
- Simultaneous Imaging of Ventilation and Gas Exchange with HyperpolarizedAmerican journal of respiratory and critical care medicine · 2022Article
- Bronchoscopic lung volume reduction: status quo.Annals of translational medicine · 2020Review
- Correlation of positron emission tomography ventilation-perfusion matching with CT densitometry in severe emphysema.EJNMMI research · 2020Article
- Endoscopic Lung Volume Reduction Results in Improvement of Diaphragm Mobility as Measured by Sonography.International journal of chronic obstructive pulmonary disease · 2020Article
- Valve therapy in patients with emphysematous type of chronic obstructive pulmonary disease (COPD): from randomized trials to patient selection in clinical practice.Journal of thoracic disease · 2018Review
- Reduced ventilation-perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium-68 V/Q photon emission tomography/computed tomography.Respirology case reports · 2017Article
- Endobronchial Valves for Endoscopic Lung Volume Reduction: Best Practice Recommendations from Expert Panel on Endoscopic Lung Volume Reduction.Respiration; international review of thoracic diseases · 2017Review
- Comparison of distinctive models for calculating an interlobar emphysema heterogeneity index in patients prior to endoscopic lung volume reduction.International journal of chronic obstructive pulmonary disease · 2017Article
- Dual-Energy Computed Tomography Compared to Lung Perfusion Scintigraphy to Assess Pulmonary Perfusion in Patients Screened for Endoscopic Lung Volume Reduction.Respiration; international review of thoracic diseasesArticle
- Use of Ventilation-Perfusion Single-Photon Emission Computed Tomography to Select the Target Lobe for Endobronchial Valve Lung Volume Reduction.Respiration; international review of thoracic diseasesObservational
- A New Oxygen Uptake Measurement Supporting Target Selection for Endobronchial Valve Treatment.Respiration; international review of thoracic diseasesArticle
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exclusion of collateral ventilation (CV) and other factors affect the clinical success of endoscopic lung volume reduction (ELVR). However, despite its benefits, the outcome of ELVR remains difficult to predict. We investigated whether clinical success could be predicted by emphysema distribution assessed by computed tomography scan and baseline perfusion assessed by perfusion scintigraphy. Data from 57 patients with no CV in the target lobe (TL) were retrospectively analyzed after ELVR with valves. Pulmonary function tests (PFT), St George's Respiratory Questionnaire (SGRQ), and 6-minute walk tests (6MWT) were performed on patients at baseline. The sample was grouped into high and low levels at the median of TL perfusion, ipsilateral nontarget lobe (INL) perfusion, and heterogeneity index (HI). These groups were analyzed for association with changes in outcome parameters from baseline to 3 months follow-up. Compared to baseline, patients showed significant improvements in PFT, SGRQ, and 6MWT (all P≤0.001). TL perfusion was not associated with changes in the outcome. High INL perfusion was significantly associated with increases in 6MWT (P=0.014), and high HI was associated with increases in forced expiratory volume in 1 second (FEV1), (P=0.012). Likewise, there were significant correlations for INL perfusion and improvement of 6MWT (r=0.35, P=0.03) and for HI and improvement in FEV1 (r=0.45, P=0.001). This study reveals new attributes that associate with positive outcomes for patient selection prior to ELVR. Patients with high perfusions in INL demonstrated greater improvements in 6MWT, while patients with high HI were more likely to respond in FEV1.
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