ArticleProceedings of the National Academy of Sciences of the United States of America2016
Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Early transcription factor activation distinguishes symbiotic from non-symbiotic bacteria during microbiome processing in a sponge.The ISME journal · 2026Article
- Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates.Nature communications · 2025Article
- A red algal polysaccharide influences the multicellular development of the choanoflagellate Salpingoeca rosetta.Current biology : CB · 2025Article
- A stress-responsive p38 signaling axis in choanoflagellates.RSC chemical biology · 2025Article
- Article
- Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies.Angewandte Chemie (International ed. in English) · 2024Article
- Cell differentiation controls iron assimilation in a choanoflagellate.bioRxiv : the preprint server for biology · 2024Article
- Article
- Outer membrane vesicles from commensal microbes contribute to the sponge Tedania sp. development by regulating the expression level of apoptosis-inducing factor (AIF).Communications biology · 2024Article
- Article
- What choanoflagellates can teach us about symbiosis.PLoS biology · 2024Article
- Identification of the regulatory roles of water qualities on the spatio-temporal dynamics of microbiota communities in the water and fish guts in the Heilongjiang River.Frontiers in microbiology · 2024Article
- Multiomics integration for the function of bacterial outer membrane vesicles in the larval settlement of marine sponges.Frontiers in microbiology · 2024Article
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
- Isolation of sulfonosphingolipids from the rosette-inducing bacteriumRSC advances · 2023Article
- Emergent community architecture despite distinct diversity in the global whale shark (Rhincodon typus) epidermal microbiome.Scientific reports · 2023Article
- Evolution of selfish multicellularity: collective organisation of individual spatio-temporal regulatory strategies.BMC ecology and evolution · 2023Article
- Photodegradation of a bacterial pigment and resulting hydrogen peroxide release enable coral settlement.Scientific reports · 2023Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In choanoflagellates, the closest living relatives of animals, multicellular rosette development is regulated by environmental bacteria. The simplicity of this evolutionarily relevant interaction provides an opportunity to identify the molecules and regulatory logic underpinning bacterial regulation of development. We find that the rosette-inducing bacterium Algoriphagus machipongonensis produces three structurally divergent classes of bioactive lipids that, together, activate, enhance, and inhibit rosette development in the choanoflagellate Salpingoeca rosetta. One class of molecules, the lysophosphatidylethanolamines (LPEs), elicits no response on its own but synergizes with activating sulfonolipid rosette-inducing factors (RIFs) to recapitulate the full bioactivity of live Algoriphagus. LPEs, although ubiquitous in bacteria and eukaryotes, have not previously been implicated in the regulation of a host-microbe interaction. This study reveals that multiple bacterially produced lipids converge to activate, enhance, and inhibit multicellular development in a choanoflagellate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.