ArticleProceedings of the National Academy of Sciences of the United States of America2016
Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 233 papers.
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Who cites it
233 citing papers in PubMed.
- Genome-wide association analysis reveals genetic architecture of fertility traits in Sahiwal heifers and cows.Tropical animal health and production · 2026Article
- Transition from Conventional to Genomic Selection (ssGBLUP) led to improve in accuracy gains and selection decisions in Sahiwal Cattle.Scientific reports · 2026Article
- Predictive models of the genetic bases underlying budding yeast fitness in multiple environments.NAR genomics and bioinformatics · 2026Article
- PGS-GS: a framework integrating polygenic scores and genomic selection in animal breeding.Briefings in bioinformatics · 2026Article
- Genomic evaluation and gene expression analysis of preimplantation embryos for enhancing cattle breeding and in vitro embryo production.The Journal of reproduction and development · 2026Review
- Different goals, common ground: A global perspective on dairy breeding objectives.JDS communications · 2026Article
- Influence of herd and environmental factors and phenotypic trends in productive and reproductive traits in dairy farms in Argentina.Tropical animal health and production · 2026Article
- Genomic selection strategies and their potential to maintain rare alleles and de-novo mutations: a long-term assessment.Genetics, selection, evolution : GSE · 2026Article
- Article
- Integrating GWAS-guided markers preselection with genomic selection enhances prediction of pulpwood-related traits in slash pine (Pinus elliottii Englem.).BMC plant biology · 2026Article
- Recent population history in Swedish cattle breeds.Genetics, selection, evolution : GSE · 2026Article
- Handmade Biopsy for Genotyping of In Vitro-Produced Bovine Embryos.Anatomia, histologia, embryologia · 2026Article
- Integrating Precision Livestock Farming and Genomic Tools for Heat Stress Mitigation in South African Dairy Cattle.Animals : an open access journal from MDPI · 2026Review
- A Comparative Review of Fertility and Semen Assessment Techniques in Farm Animals.Animals : an open access journal from MDPI · 2026Review
- Deciphering autosomal and X-linked genetic effects of early growth traits in Murciano-Granadina goats via a multivariate animal model.Veterinary and animal science · 2026Article
- GWKBR: a novel method integrating machine learning and Bayesian inference framework to improve genomic prediction accuracy.Briefings in bioinformatics · 2026Article
- Skim-sequencing for genomic selection in wheat: a comparison of marker platforms.The plant genome · 2026Article
- Strategies to improve on selection based on estimated breeding values.Genetics, selection, evolution : GSE · 2026Article
- Article
- Spatial modelling improves genomic evaluation in Tanzanian smallholder admixed dairy cattle.Genetics, selection, evolution : GSE · 2026Article
173 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seven years after the introduction of genomic selection in the United States, it is now possible to evaluate the impact of this technology on the population. Selection differential(s) (SD) and generation interval(s) (GI) were characterized in a four-path selection model that included sire(s) of bulls (SB), sire(s) of cows (SC), dam(s) of bulls (DB), and dam(s) of cows (DC). Changes in SD over time were estimated for milk, fat, and protein yield; somatic cell score (SCS); productive life (PL); and daughter pregnancy rate (DPR) for the Holstein breed. In the period following implementation of genomic selection, dramatic reductions were seen in GI, especially the SB and SC paths. The SB GI reduced from ∼7 y to less than 2.5 y, and the DB GI fell from about 4 y to nearly 2.5 y. SD were relatively stable for yield traits, although modest gains were noted in recent years. The most dramatic response to genomic selection was observed for the lowly heritable traits DPR, PL, and SCS. Genetic trends changed from close to zero to large and favorable, resulting in rapid genetic improvement in fertility, lifespan, and health in a breed where these traits eroded over time. These results clearly demonstrate the positive impact of genomic selection in US dairy cattle, even though this technology has only been in use for a short time. Based on the four-path selection model, rates of genetic gain per year increased from ∼50-100% for yield traits and from threefold to fourfold for lowly heritable traits.
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