ArticleInfection and immunity2016
Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Possible correlation of specific bacteria detected by using a novel screening method and periodontal disease in dogs.The Journal of veterinary medical science · 2025Article
- Assessment of periodontitis vaccine using three different bacterial outer membrane vesicles in canine model.mSphere · 2025Article
- Bacterial DNA and serum IgG antibody titer assays for assessing infection of human-pathogenic and dog-pathogenicHeliyon · 2024Article
- Characterization of oral microbiota in 6-8-month-old small breed dogs.BMC veterinary research · 2024Article
- Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs.Animals : an open access journal from MDPI · 2023Article
- The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats.Animals : an open access journal from MDPI · 2023Article
- Phylogenomic analysis of theFrontiers in microbiology · 2023Article
- Evaluation of the antibacterial effect of Epigallocatechin gallate on the major pathogens of canine periodontal disease and therapeutic effects on periodontal disease mice.Frontiers in microbiology · 2023Article
- Article
- Erythritol inhibits the growth of periodontal-disease-associated bacteria isolated from canine oral cavity.Heliyon · 2022Article
- Salivary microbiota may predict the presence of esophageal squamous cell carcinoma.Genes & diseases · 2022Article
- Detection of Periodontal Pathogens from Dental Plaques of Dogs with and without Periodontal Disease.Pathogens (Basel, Switzerland) · 2022Article
- Study of microbiocenosis of canine dental biofilms.Scientific reports · 2021Article
- Existence of natural mouse IgG mAbs recognising epitopes shared by malondialdehyde acetaldehyde adducts andInnate immunity · 2021Article
- Mucosal Vaccination Against Periodontal Disease: Current Status and Opportunities.Frontiers in immunology · 2021Review
- Phylogenetic diversity inJournal of oral microbiology · 2020Article
- Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388.Pharmacology research & perspectives · 2020Article
- Purification and characterization of a fimbrial protein from Porphyromonas salivosa ATCC 49407.The Journal of veterinary medical science · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a significant problem in companion animals, and yet little is known about the disease-associated microbiota. A major virulence factor for the human periodontal pathogen Porphyromonas gingivalis is the lysyl- and arginyl-specific proteolytic activity of the gingipains. We screened several Porphyromonas species isolated from companion animals-P. asaccharolytica, P. circumdentaria, P. endodontalis, P. levii, P. gulae, P. macacae, P. catoniae, and P. salivosa-for Lys- and Arg-specific proteolytic activity and compared the epithelial and macrophage responses and induction of alveolar bone resorption of the protease active species to that of Porphyromonas gingivalis Only P. gulae exhibited Lys-and Arg-specific proteolytic activity. The genes encoding the gingipains (RgpA/B and Kgp) were identified in the P. gulae strain ATCC 51700 and all publicly available 12 draft genomes of P. gulae strains. P. gulae ATCC 51700 induced levels of alveolar bone resorption in an animal model of periodontitis similar to those in P. gingivalis W50 and exhibited a higher capacity for autoaggregation and binding to oral epithelial cells with induction of apoptosis. Macrophages (RAW 264.7) were found to phagocytose P. gulae ATCC 51700 and the fimbriated P. gingivalis ATCC 33277 at similar levels. In response to P. gulae ATCC 51700, macrophages secreted higher levels of cytokines than those induced by P. gingivalis ATCC 33277 but lower than those induced by P. gingivalis W50, except for the interleukin-6 response. Our results indicate that P. gulae exhibits virulence characteristics similar to those of the human periodontal pathogen P. gingivalis and therefore may play a key role in the development of periodontitis in companion animals.
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