Trial reportHuman molecular genetics2016
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
Abstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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29citing papers in PubMed, 2 pooled it
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Family history and breast cancer risk for Asian women: a systematic review and meta-analysis.BMC medicine · 2023Pooled it
- Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.Nature communications · 2020Pooled it
- Genetic and lifestyle factors for breast cancer risk assessment in Southeast China.Cancer medicine · 2023Trial
- A reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case-control analysis.Human molecular genetics · 2026Article
- Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.Nature genetics · 2025Observational
- Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities.Cell genomics · 2024Article
- Exploring Disparities in Pancreatic Ductal Adenocarcinoma Outcomes among Asian and Pacific Islander Subgroups.Cancer research communications · 2024Article
- A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer.American journal of human genetics · 2024Article
- No association between genetically predicted C-reactive protein levels and colorectal cancer survival in Korean: two-sample Mendelian randomization analysis.Epidemiology and health · 2023Article
- Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics.American journal of human genetics · 2022Article
- Article
- Sequencing of Chromosomal Locus 6q25.1 Revealed Two Significant SNPs rs2046210 and rs2046211 Associated with Breast Cancer: A Case-Control Study in Egyptian Women.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women.JAMA network open · 2022Article
- Article
- Cancer health disparities in racial/ethnic minorities in the United States.British journal of cancer · 2021Review
- Cancer classification based on chromatin accessibility profiles with deep adversarial learning model.PLoS computational biology · 2020Article
- Breast Cancer Risk Prediction in Korean Women: Review and Perspectives on Personalized Breast Cancer Screening.Journal of breast cancer · 2020Review
- The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population.Molecular medicine (Cambridge, Mass.) · 2020Article
- Identification of NovelFrontiers in genetics · 2020Article
- Identification of 5 Gene Signatures in Survival Prediction for Patients with Lung Squamous Cell Carcinoma Based on Integrated Multiomics Data Analysis.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
31 authors.
Mi-Ryung HanDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Jirong LongDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA jirong.long@vanderbilt.edu.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.
Siew-Kee LowLaboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 351-0198, Japan.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju 61469, South Korea.
Ying ZhengShanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Qiuyin CaiDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Jiajun ShiDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Xingyi GuoDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Keitaro MatsuoDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Motoki IwasakiEpidemiology Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Chen-Yang ShenInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Mi Kyung KimDivision of Cancer Epidemiology and Management, National Cancer Center, Gyeonggi-do 10408, South Korea.
Wanqing WenDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Bingshan LiDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Atsushi TakahashiLaboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 351-0198, Japan.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju 61469, South Korea.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China.
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Yoshio KasugaDepartment of Surgery, Nagano Matsushiro General Hospital, Nagano 381-1231, Japan.
Dong-Young NohCancer Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Koichi MatsudaLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo 108-8639, Japan.
Min Ho ParkDepartment of Surgery, Chonnam National University Medical School, Gwangju 61469, South Korea.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China.
Hiroji IwataDepartment of Breast Oncology, Aichi Cancer Center Central Hospital, Nagoya 464-8681, Japan.
Shoichiro TsuganeResearch Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Sue K ParkDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.
Michiaki KuboLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 351-0198, Japan.
Xiao-Ou ShuDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Daehee KangDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.
Wei ZhengDepartment of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MShanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MConsortium Study to Identify Breast Cancer Susceptibility LociR01CA148667 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LONG, JIRONG, ZHENG, WEI · 2011 to 2015
$3.3MGenetic Factors for Breast Cancer- A genome Wide StudyR01CA124558 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 2008 to 2012
$3.1MBreast Cancer Survival: Lifestyle and Genetic DeterminantsR01CA118229 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2007 to 2010
$2.9MGenome-wide Copy Number Variation and Breast Cancer RiskR01CA137013 · NCI · VANDERBILT UNIVERSITY · PI LONG, JIRONG · 2009 to 2012
$2.4MSoyfood, Gene Polymorphisms and Endometrial Cancer RiskR01CA092585 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2010
$2.3MCell Cycle/Apoptosis Gene Variants and Breast Cancer RiskR01CA122756 · NCI · VANDERBILT UNIVERSITY · PI CAI, QIUYIN · 2008 to 2011
$2.1MRole of Shh in developmental patterning and proliferation of digit skeletonZ01BC011118 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MACKEM, SUSAN · 2008 to 2008
$297kIntramural NIH HHS Z01 BC011118NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA092585NCI NIH HHS R01 CA118229NCI NIH HHS R01 CA122756NCI NIH HHS R01 CA124558NCI NIH HHS R01 CA137013NCI NIH HHS R01 CA148667NCI NIH HHS R37 CA070867NCI NIH HHS U19 CA148065NCI NIH HHS UM1 CA182910
Abstract
Breast cancer is one of the most common malignancies among women worldwide. Genetic factors have been shown to play an important role in breast cancer aetiology. We conducted a two-stage genome-wide association study (GWAS) including 14 224 cases and 14 829 controls of East Asian women to search for novel genetic susceptibility loci for breast cancer. Single nucleotide polymorphisms (SNPs) in two loci were found to be associated with breast cancer risk at the genome-wide significance level. The first locus, represented by rs12118297 at 1p22.3 (near the LMO4 gene), was associated with breast cancer risk with odds ratio (OR) and (95% confidence interval (CI)) of 0.91 (0.88-0.94) and a P-value of 4.48 × 10
Indexed as
Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideAsia, EasternAsian PeopleBreast NeoplasmsFemaleHumansMiddle Aged
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