Evidence map›Paper›PMID 27354348›Full record

ReviewFEMS microbiology reviews2016

Specificity and complexity in bacterial quorum-sensing systems.

Lisa A Hawver, Sarah A Jung, Wai-Leung Ng

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 281 citations in OpenAlex.

  1. Review
  2. Article
  3. Identification ofMicroorganisms · 2026
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  12. LtrB inhibitsCurrent research in food science · 2026
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lisa A HawverDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.
Sarah A JungDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Wai-Leung NgDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA Wai-Leung.Ng@tufts.edu.
Tufts University · US

Funding

MOLECULAR ANALYSIS OF MICROBIAL PATHOGENST32AI007422 · NIAID · TUFTS UNIVERSITY BOSTON · PI Ralph R. Isberg · 1992 to 2026
$5.7M
SIGNALING MECHANISMS IN VIBRIO CHOLERAE PARALLEL QUORUM SENSING PATHWAYSR01AI121337 · NIAID · TUFTS UNIVERSITY BOSTON · PI NG, WAI-LEUNG · 2016 to 2025
$4.5M
NIAID NIH HHS R01 AI121337NIAID NIH HHS T32 AI007422
6 · The paper itself

Abstract

Quorum sensing (QS) is a microbial cell-to-cell communication process that relies on the production and detection of chemical signals called autoinducers (AIs) to monitor cell density and species complexity in the population. QS allows bacteria to behave as a cohesive group and coordinate collective behaviors. While most QS receptors display high specificity to their AI ligands, others are quite promiscuous in signal detection. How do specific QS receptors respond to their cognate signals with high fidelity? Why do some receptors maintain low signal recognition specificity? In addition, many QS systems are composed of multiple intersecting signaling pathways: what are the benefits of preserving such a complex signaling network when a simple linear 'one-to-one' regulatory pathway seems sufficient to monitor cell density? Here, we will discuss different molecular mechanisms employed by various QS systems that ensure productive and specific QS responses. Moreover, the network architectures of some well-characterized QS circuits will be reviewed to understand how the wiring of different regulatory components achieves different biological goals.

Indexed as

Bacterial Physiological PhenomenaBacteriaGene Expression Regulation, BacterialQuorum SensingRepressor ProteinsSignal TransductionTrans-ActivatorsLuxR autoinducer binding proteinsRepressor ProteinsTrans-Activatorschemical signalinggene expressiongroup behaviorintercellular communicationregulatory network

Identifiers

PMID27354348
PMCPMC5007282
OpenAlexW2471638024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.