Evidence map›Paper›PMID 27354215›Full record

ArticleThe Annals of otology, rhinology, and laryngology2016

Quantitative Evaluation of Adult Subglottic Stenosis Using Intraoperative Long-range Optical Coherence Tomography.

Giriraj K Sharma, Anthony Chin Loy, Erica Su, Joe Jing, Zhongping Chen, Brian J-F Wong, Sunil Verma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Annals of otology, rhinology, and laryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Guideline
  2. Automated vision-based assistance tools in bronchoscopy: stenosis severity estimation.International journal of computer assisted radiology and surgery · 2025
    Article
  3. Review
  4. Article
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  10. Article
  11. Quantifying Anatomic Deformations During Laryngoscopy.Annals of biomedical engineering · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Giriraj K SharmaDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Anthony Chin LoyDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Erica SuBeckman Laser Institute, University of California, Irvine, California, USA.
Joe JingBeckman Laser Institute, University of California, Irvine, California, USA Department of Biomedical Engineering, University of California, Irvine, California, USA.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, California, USA Department of Biomedical Engineering, University of California, Irvine, California, USA.
Brian J-F WongDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.
Sunil VermaDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA University Voice and Swallowing Center, University of California, Irvine, California, USA verma@uci.edu.
University of California, Irvine · USBeckman Laser Institute and Medical Clinic · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Modeling the Pediatric Upper Airway using A-OCT and Computational Fluid DynamicsR01HL105215 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ELGHOBASHI, SAID E. · 2010 to 2013
$3.7M
Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCTR01HL103764 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WONG, BRIAN · 2010 to 2014
$3.1M
NHLBI NIH HHS R01 HL103764NHLBI NIH HHS R01 HL105215NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

objectivesTo determine the feasibility of long-range optical coherence tomography (LR-OCT) as a tool to intraoperatively image and measure the subglottis and trachea during suspension microlaryngoscopy before and after endoscopic treatment of subglottic stenosis (SGS).

methodsLong-range optical coherence tomography of the adult subglottis and trachea was performed during suspension microlaryngoscopy before and after endoscopic treatment for SGS. The anteroposterior and transverse diameters, cross-sectional area (CSA), distance from the vocal cords, and length of the SGS were measured using a MATLAB software. Pre-intervention and postintervention airway dimensions were compared. Three-dimensional volumetric airway reconstructions were generated using medical image processing software (MIMICS).

resultsIntraoperative LR-OCT imaging was performed in 3 patients undergoing endoscopic management of SGS. Statistically significant differences in mean anteroposterior diameter (P < .01), transverse diameter (P < .001), and CSA (P < .001) were noted between pre-intervention and postintervention data. Three-dimensional airway models were viewed in cross-sectional format and via virtual "fly through" bronchoscopy.

conclusionsThis is the first report of intraoperative LR-OCT of the subglottic and tracheal airway before and after surgical management of SGS in humans. Long-range optical coherence tomography offers a practical means to measure the dimensions of SGS and acquire objective data on the response to endoscopic treatment of SGS.

Indexed as

AdultAscorbic AcidFemaleFerrous CompoundsHumansImage Processing, Computer-AssistedImaging, Three-DimensionalIntraoperative CareLaryngoscopyLaryngostenosisLarynxOrgan SizeTomography, Optical CoherenceTracheaAscorbic AcidFerrous Compoundsiron(II)-ascorbic acid complexairway measurementdirect laryngoscopyoptical coherence tomographysubglottic stenosissuspension microlaryngoscopy

Identifiers

PMID27354215
PMCPMC5127265
OpenAlexW2471762787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.