ArticleCirculation research2016
Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity.
Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm.American journal of physiology. Heart and circulatory physiology · 2025Article
- Mice Models for Peripheral Denervation to Enhance Vascular Regeneration.Tissue engineering. Part C, Methods · 2025Article
- Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling.JVS-vascular science · 2024Article
- Deficiency of neuropeptide Y attenuates neointima formation after vascular injury in mice.BMC cardiovascular disorders · 2023Article
- Environmental and intrinsic modulations of venous differentiation.Cellular and molecular life sciences : CMLS · 2022Article
- Neuregulin-1, in a Conducive Milieu with Wnt/BMP/Retinoic Acid, Prolongs the Epicardial-Mediated Cardiac Regeneration Capacity of Neonatal Heart Explants.Journal of stem cells & regenerative medicine · 2021Article
- Arterial Venous Differentiation for Vascular Bioengineering.Annual review of biomedical engineering · 2018Review
- The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling.The Journal of biological chemistry · 2018Article
- L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.JCI insight · 2017Article
- Vascular heterogeneity and specialization in development and disease.Nature reviews. Molecular cell biology · 2017Review
- Plasticity of Arterial and Venous Endothelial Cell Identity: Some Nerve!Circulation research · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleArterial endothelial cells are morphologically, functionally, and molecularly distinct from those found in veins and lymphatic vessels. How arterial fate is acquired during development and maintained in adult vessels is incompletely understood.
objectiveWe set out to identify factors that promote arterial endothelial cell fate in vivo. METHODS AND
resultsWe developed a functional assay, allowing us to monitor and manipulate arterial fate in vivo, using arteries isolated from quails that are grafted into the coelom of chick embryos. Endothelial cells migrate out from the grafted artery, and their colonization of host arteries and veins is quantified. Here we show that sympathetic innervation promotes arterial endothelial cell fate in vivo. Removal of sympathetic nerves decreases arterial fate and leads to colonization of veins, whereas exposure to sympathetic nerves or norepinephrine imposes arterial fate. Mechanistically, sympathetic nerves increase endothelial ERK (extracellular signal-regulated kinase) activity via adrenergic α1 and α2 receptors.
conclusionsThese findings show that sympathetic innervation promotes arterial endothelial fate and may lead to novel approaches to improve arterialization in human disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.