Evidence map›Paper›PMID 27354093›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Evaluation of [

Heli Savolainen, Albert D Windhorst, Philip H Elsinga, Mariangela Cantore, Nicola A Colabufo, Antoon Tm Willemsen, Gert Luurtsema

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

  1. Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak SubstrateJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Trial
  2. European heart journal open · 2025
    Article
  3. Article
  4. Designing a Small Molecule for PET Radiotracing: [Molecules (Basel, Switzerland) · 2025
    Review
  5. Imaging the Activity of Efflux Transporters at the Blood-Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  6. Article
  7. Article
  8. Oral Administration of [Molecular imaging and biology · 2025
    Article
  9. Evaluating image-derived input functions for cerebral [Frontiers in nuclear medicine · 2025
    Article
  10. [Fluids and barriers of the CNS · 2024
    Article
  11. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  12. Review
  13. Quantification of P-glycoprotein function at the human blood-brain barrier using [European journal of nuclear medicine and molecular imaging · 2023
    Article
  14. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. First clinical assessment of [Annals of nuclear medicine · 2021
    Article
  20. Molecular pharmaceutics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Heli Savolainen1 Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Albert D Windhorst2 Department of Radiology and Nuclear Medicine, VU University Medical Center Amsterdam, Amsterdam, Netherlands.
Philip H Elsinga1 Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Mariangela Cantore3 Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, Bari, Italy.
Nicola A Colabufo3 Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, Bari, Italy.
Antoon Tm Willemsen1 Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Gert Luurtsema1 Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
University Medical Center Groningen · NLUniversity of Bari Aldo Moro · ITUniversity of Groningen · NLAmsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P-glycoprotein is a protective efflux transporter at the blood-brain barrier showing altered function in many neurological disorders. The purpose of this study was to validate [

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierFluorine RadioisotopesIsoquinolinesKineticsMalePositron-Emission TomographyRadiopharmaceuticalsRats, Sprague-DawleyTetrahydronaphthalenesTissue DistributionATP Binding Cassette Transporter, Subfamily B, Member 1Fluorine RadioisotopesIsoquinolinesMC225 compoundRadiopharmaceuticalsTetrahydronaphthalenesBlood–brain barrierbrain imagingbreast cancer resistance proteinkinetic modelingpositron emission tomography

Identifiers

PMID27354093
PMCPMC5453451
OpenAlexW2465584641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.