Evidence map›Paper›PMID 27354047›Full record

ArticleEuropean heart journal2016

Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction.

Barry A Borlaug, Garvan C Kane, Vojtech Melenovsky, Thomas P Olson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 3 pooled it
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 3 syntheses or guidelines pooled it, 361 citations in OpenAlex.

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  11. Article
  12. Assessment of Exercise Intolerance and Evaluation for HFpEF: A Literature Review of Pathophysiology, Diagnosis, and Management.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
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  15. Observational
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  20. Heart failure with preserved ejection fraction: current insights and emerging therapeutic directions.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Review

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Barry A BorlaugThe Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55906, USA borlaug.barry@mayo.edu.
Garvan C KaneThe Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55906, USA.
Vojtech MelenovskyThe Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55906, USA.
Thomas P OlsonThe Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55906, USA.
Mayo Clinic · US

Funding

Peripheral Mechanisms of Cardiopulmonary Control during ExerciseR01HL126638 · NHLBI · MAYO CLINIC ROCHESTER · PI OLSON, THOMAS PATRICK · 2015 to 2019
$2.9M
NHLBI NIH HHS R01 HL126638
6 · The paper itself

Abstract

backgroundExercise intolerance is common in people with heart failure and preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction has been shown at rest in HFpEF but little data are available regarding dynamic RV-pulmonary artery (PA) coupling during exercise. METHODS AND

resultsSubjects with HFpEF (n = 50) and controls (n = 24) prospectively underwent invasive cardiopulmonary exercise testing using high-fidelity micromanometer catheters along with simultaneous assessment of RV and left ventricular (LV) mechanics by echocardiography. Compared with controls at rest, subjects with HFpEF displayed preserved RV systolic and diastolic mechanics (RV s' and e'), impaired LV s' and e', higher biventricular filling pressures, and higher pulmonary artery pressures. On exercise, subjects with HFpEF displayed less increase in stroke volume, heart rate, and cardiac output (CO), with blunted increase in CO relative to O

conclusionsIn addition to limited LV reserve, patients with HFpEF display impaired RV reserve during exercise that is associated with high filling pressures and inadequate CO responses. These findings highlight the importance of biventricular dysfunction in HFpEF and suggest that novel therapies targeting myocardial reserve in both the left and right heart may be effective to improve clinical status.

Indexed as

Heart VentriclesHeart FailureHumansPulmonary ArteryStroke VolumeVentricular Dysfunction, RightDiastolic functionExerciseHaemodynamicsHeart failureHeart failure with preserved ejection fractionPulmonary hypertensionRight ventricular function

Identifiers

PMID27354047
PMCPMC8483148
OpenAlexW2465331900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.