ReviewLancet (London, England)2016
The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia.
Review in Lancet (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 81 citations in OpenAlex.
- Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease.Blood advances · 2024Trial
- Trial
- Inhaled corticosteroid use to prevent severe vaso-occlusive episode recurrence in children between 1 and 4 years of age with sickle cell disease: a multicenter feasibility trial.American journal of hematology · 2018Trial
- Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease.Blood advances · 2018Trial
- Losartan for the nephropathy of sickle cell anemia: A phase-2, multicenter trial.American journal of hematology · 2017Trial
- Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia.British journal of haematology · 2026Article
- Article
- Nutritional status and clinical severity in children with sickle cell disease and confirmed asthma: a multicentre observational study.BMC pediatrics · 2026Observational
- Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.American journal of hematology · 2026Article
- Association of Asthma with Acute Vaso-Occlusive Crisis Among French Guianese Children with Sickle Cell Disease.Indian journal of pediatrics · 2026Article
- Patients with sickle cell disease and asthma have a higher risk for acute chest syndrome: A systematic review and meta-analysis of observational studies.Experimental and therapeutic medicine · 2026Article
- Article
- Determinants of clinical severity in children with sickle cell disease and confirmed asthma.PloS one · 2026Observational
- Emergency care for children with sickle cell disease: a focus on pain and fever.Expert review of hematology · 2025Review
- Airborne injustice: a preliminary exploration of the associations between pollutants and hospitalizations, sleep, and cognition in children and young adults living with sickle cell disease.Journal of pediatric psychology · 2025Article
- Article
- Respiratory phenotype and health care utilization patterns by adults with sickle cell disease.Blood advances · 2025Article
- Related Risk Factors That Predict Moderate to Severe Asthma Attack in Children: Analysis Based on Logistic Regression and Decision Tree.International journal of general medicine · 2025Article
- Asthma Is an Independent Risk Factor for Acute Chest Syndrome in Children with Sickle Cell Disease in French Guiana.Children (Basel, Switzerland) · 2024Article
- Effects of Air Pollution on Respiratory Events and Pain Crises among Children with Sickle Cell Disease in New York City.Annals of the American Thoracic Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell disease. Asthma is common in children with sickle-cell disease and is associated with increased incidence of vaso-occlusive pain events, acute chest syndrome episodes, and earlier death. Risk factors for asthma exacerbation and an acute chest syndrome episode are similar, and both can present with shortness of breath, chest pain, cough, and wheezing. Despite overlapping risk factors and symptoms, an acute exacerbation of asthma or an episode of acute chest syndrome are two distinct entities that need disease-specific management strategies. Although understanding has increased about asthma as a comorbidity in sickle-cell disease and its effects on morbidity, substantial gaps remain in knowledge about best management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.