ReviewChemical reviews2016
Hydrogenase Enzymes and Their Synthetic Models: The Role of Metal Hydrides.
Review in Chemical reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed.
- Effects of Ligand Electronic Environment on Electrocatalytic Proton Reduction by Cobalt Complexes.Chemistry, an Asian journal · 2026Article
- Dual Activation of HAngewandte Chemie (International ed. in English) · 2026Article
- A secondary-sphere proton channel accelerating metal-hydride formation in Mn(i) catalysts for selective COChemical science · 2026Article
- Unique Metal-Ligand Proton Tautomerism Underlying the Reversible Electrocatalytic NADJournal of the American Chemical Society · 2026Article
- Bioinspired Copper(II) Complexes With N,S-Donor Ligands: Structure-Activity Relationships and Mechanistic Insights for Aqueous Hydrogen Evolution Reaction.ChemSusChem · 2026Article
- Diiron(I) Bis(cyclopentadienyl) Complexes with Bridging Iminium Ligands: From Foundational Organometallic Chemistry to Unique Reactivity and Biological Potential.Accounts of chemical research · 2026Article
- Quantum Life Science: A Paradigm for Life Science Research.ACS nano · 2026Review
- Synthesis, Properties, and Electrochemical Proton Reduction of a Homoleptic Tetrathiolato Ni-Site Model of [NiFe]-Hydrogenase.Inorganic chemistry · 2025Article
- NRVS Spectroscopy Resolves Distinct Bridging Hydride Intermediates in [NiFe]-Hydrogenase.Journal of the American Chemical Society · 2025Article
- Revisiting H‑BondACS omega · 2025Article
- Hydrogen-Producing Catalysts Based on Ferredoxin Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- NRVS of FeS cluster proteins & models - A bestiary of nifty normal modes.Journal of inorganic biochemistry · 2025Review
- Tuning the Electronic and Molecular Structures of Bioinspired Heterodinuclear NiFe Catalyst for Enhanced Catalytic HACS organic & inorganic Au · 2025Article
- Article
- Markovnikov-Selective Electrocatalytic Hydroalkylation Enabled by Metal-Ligand Cooperative Storage of H-Atom Equivalents.ACS catalysis · 2025Article
- Computational Modeling and Experimental Approaches for Understanding the Mechanisms of [FeFe]-Hydrogenase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- How Geometric Constraints Control the Hydride Position and Activity in [NiFe]-Hydrogenases and Their Biomimetic Complexes.Inorganic chemistry · 2025Article
- Substrate-Dependent Hydridic and Radical Reactivity of Triiron Hydride Clusters.Inorganic chemistry · 2025Article
- Stabilization of a Terminal Hydride Through Regioselective Protonation in a Diiron Complex Inspired by [FeFe]-Hydrogenase.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Controlling the Size of Molecular Copper Clusters Supported by a Multinucleating Macrocycle.Inorganic chemistry · 2024Article
51 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Hydrogenase enzymes efficiently process H2 and protons at organometallic FeFe, NiFe, or Fe active sites. Synthetic modeling of the many H2ase states has provided insight into H2ase structure and mechanism, as well as afforded catalysts for the H2 energy vector. Particularly important are hydride-bearing states, with synthetic hydride analogues now known for each hydrogenase class. These hydrides are typically prepared by protonation of low-valent cores. Examples of FeFe and NiFe hydrides derived from H2 have also been prepared. Such chemistry is more developed than mimicry of the redox-inactive monoFe enzyme, although functional models of the latter are now emerging. Advances in physical and theoretical characterization of H2ase enzymes and synthetic models have proven key to the study of hydrides in particular, and will guide modeling efforts toward more robust and active species optimized for practical applications.
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