ArticleScientific reports2016
Osteopontin deficiency reduces kidney damage from hypercholesterolemia in Apolipoprotein E-deficient mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Systems biology approach uncovers candidates for kidney-heart interorgan crosstalk after myocardial infarction.Scientific reports · 2025Article
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- PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.Molecular medicine (Cambridge, Mass.) · 2022Article
- Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans.JCI insight · 2021Article
- Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.Experimental and therapeutic medicine · 2021Article
- Circulating Osteoprotegerin in Chronic Kidney Disease and All-Cause Mortality.International journal of general medicine · 2021Article
- Sarpogrelate and rosuvastatin synergistically ameliorate aortic damage induced by hyperlipidemia in apolipoprotein E-deficient mice.Experimental and therapeutic medicine · 2020Article
- Disparate Effects of Diabetes and Hyperlipidemia on Experimental Kidney Disease.Frontiers in physiology · 2020Article
- Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney.Developmental cell · 2019Article
- Ghrelin-mediated pathway in Apolipoprotein-E deficient mice: a survival system.American journal of translational research · 2019Article
- Thymoquinone reduces cardiac damage caused by hypercholesterolemia in apolipoprotein E-deficient mice.Lipids in health and disease · 2018Article
- Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.JCI insight · 2018Article
- Bagging Nearest-Neighbor Prediction independence Test: an efficient method for nonlinear dependence of two continuous variables.Scientific reports · 2017Article
- The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Reduces Aortic Damage from Hypercholesterolaemia in Apolipoprotein E-Deficient Mice.Biomedicine hubArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
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Abstract
Hypercholesterolemia is a well-established risk factor for kidney injury, which can lead to chronic kidney disease (CKD). Osteopontin (OPN) has been implicated in the pathology of several renal conditions. This study was to evaluate the effects of OPN on hypercholesterolemia induced renal dysfunction. Eight-week-old male mice were divided into 4 groups: apolipoprotein E knockout (ApoE(-/-)) and ApoE/OPN knockout (ApoE(-/-)/OPN(-/-)) mice fed a normal diet (ND) or high cholesterol diet (HD). After 4 weeks, Periodic acid-Schiff (PAS) and oil red O staining revealed excessive lipid deposition in the glomeruli of ApoE(-/-)HD mice, however, significantly suppressed in ApoE(-/-)/OPN(-/-)HD mice. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression was lower in the glomeruli of ApoE(-/-)/OPN(-/-)HD mice than ApoE(-/-)HD mice. In vitro study, primary mesangial cells were incubated with recombinant mouse OPN (rmOPN). RmOPN induced LOX-1 mRNA and protein expression in primary mesangial cells. Pre-treatment with an ERK inhibitor suppressed the LOX-1 gene expression induced by rmOPN. These results indicate that OPN contributes to kidney damage in hypercholesterolemia and suggest that inhibition of OPN may provide a potential therapeutic target for the prevention of hypercholesterolemia.
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