ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016
Positive Lymph Node Ratio as an Indicator of Prognosis and Local Tumor Clearance in N3 Gastric Cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Factors Influencing Survival After Curative Gastrectomy in Oligometastatic Gastric Cancer: A Single-Center Study.Cancer management and research · 2026Article
- Positive lymph node ratio as a nodal staging system to avoid stage migration between remnant and primary proximal gastric cancers.Scientific reports · 2025Article
- Advancing the Understanding and Treatment of Cancer Cachexia: Mechanisms, Therapeutic Approaches, and Future Opportunities.Cancer management and research · 2025Review
- Machine learning methods predict recurrence of pN3b gastric cancer after radical resection.Translational cancer research · 2024Article
- Evaluation of the prognostic value of negative to positive lymph node ratio in gastric cancer: results from multi-institutional cohorts from western and eastern datasets - Cohort study.Annals of medicine and surgery (2012) · 2023Article
- Evaluating prognostic value and stage migration effects using a positive lymph node ratio in adenocarcinoma of the esophagogastric junction.BMC cancer · 2023Article
- Treatment Outcomes and Prognostic Factors in N3 Stage Gastric Cancer After Curative Resection: A Real World Data.Cancer management and research · 2023Article
- Lymph node response to neoadjuvant chemotherapy as an independent prognostic factor in gastric cancer.Oncology letters · 2022Article
- Preoperative Low Prealbumin Is Associated With Recurrence in Patients With Stage II/III Gastric Cancer After Laparoscopic D2 Gastrectomy.Frontiers in surgery · 2022Article
- A Novel Approach for Gastric Cancer Staging in Elderly Patients Based on the Lymph Node Ratio.Journal of gastric cancer · 2021Article
- Positive lymph node ratio as a novel indicator of prognosis in gastric signet ring cell carcinoma: a population-based retrospective study.Translational cancer research · 2020Article
- Development and validation of a prognostic nomogram for predicting early recurrence after curative resection of stage II/III gastric cancer.World journal of surgical oncology · 2019Article
- Clinical significance of neutrophil-to-lymphocyte ratio as a predictor of lymph node metastasis in gastric cancer.BMC cancer · 2019Article
- Essential updates 2017/2018: Recent topics in the treatment and research of gastric cancer in Japan.Annals of gastroenterological surgery · 2019Review
- Is curative gastrectomy justified for gastric cancer with cytology positive as the only stage IV factor?Langenbeck's archives of surgery · 2019Article
- A homogenized approach to classify advanced gastric cancer patients with limited and adequate number of pathologically examined lymph nodes.Cancer communications (London, England) · 2019Article
- A modified subclassification to evaluate the survival of patients with N3 gastric cancer: an international database study.BMC cancer · 2019Article
- Prognostic value of the metastatic lymph node ratio in patients with pancreatic cancer.International journal of clinical and experimental pathology · 2019Article
- Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems.Oncology letters · 2019Article
- Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma.Journal of gastrointestinal oncology · 2018Article
Corrections and comments
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Authors and funding
15 authors.
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Abstract
backgroundNodal metastasis is an important clinical issue in gastric cancer patients. This study was designed to investigate the clinical usefulness of the positive lymph node ratio (PLNR), which reflects both metastatic and retrieved lymph node numbers, in patients with pN3 gastric cancer.
methodsWe retrospectively analyzed the records of 138 consecutive pN3 patients who underwent curative gastrectomy with lymphadenectomy from 2000 to 2012.
resultsA PLNR of 0.4 was proved to be the best cutoff value to stratify the prognosis of patients with pN3 gastric cancer (P < 0.001). Univariate and multivariate analyses revealed that older age, larger tumor size (≥10 cm), and PLNR ≥ 0.4 [P < 0.001, HR 3.1 (95 % CI 1.7-5.4)] were independent prognostic factors in pN3 gastric cancer. Regarding the recurrence, patients with PLNR <0.4 had a significantly lower rate of lymph node recurrence than those with PLNR ≥0.4 (P = 0.020). There was no significant difference in the lymph node recurrence rate between N3a and N3b patients in the PLNR <0.4 group [P = 0.546, 11.6 % (7/60) vs. 12.5 (1/8)], indicating a better local control regardless of pN3 subgroups.
conclusionsPLNR is useful to stratify the prognosis and evaluate the extent of local tumor clearance in pN3 gastric cancer.
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