Evidence map›Paper›PMID 27353257›Full record

ReviewAgeing research reviews2016

A synopsis on aging-Theories, mechanisms and future prospects.

João Pinto da Costa, Rui Vitorino, Gustavo M Silva, Christine Vogel, Armando C Duarte, Teresa Rocha-Santos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Evaluation ofJMIR research protocols · 2026
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

João Pinto da CostaCESAM and Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Electronic address: jpintocosta@ua.pt.
Rui VitorinoDepartment of Medical Sciences, Institute for Biomedicine-iBiMED, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal; Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal.
Gustavo M SilvaDepartment of Biology, Center for Genomics and Systems Biology, NY, NY 10003, USA.
Christine VogelDepartment of Biology, Center for Genomics and Systems Biology, NY, NY 10003, USA.
Armando C DuarteCESAM and Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Teresa Rocha-SantosCESAM and Department of Chemistry, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.

Funding

Robust statistical approaches for decoding protein and mRNA expression regulationR01GM113237 · NIGMS · NEW YORK UNIVERSITY · PI VOGEL, CHRISTINE · 2014 to 2017
$1.5M
NIGMS NIH HHS R01 GM113237
6 · The paper itself

Abstract

Answering the question as to why we age is tantamount to answering the question of what is life itself. There are countless theories as to why and how we age, but, until recently, the very definition of aging - senescence - was still uncertain. Here, we summarize the main views of the different models of senescence, with a special emphasis on the biochemical processes that accompany aging. Though inherently complex, aging is characterized by numerous changes that take place at different levels of the biological hierarchy. We therefore explore some of the most relevant changes that take place during aging and, finally, we overview the current status of emergent aging therapies and what the future holds for this field of research. From this multi-dimensional approach, it becomes clear that an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why we age, is necessary.

Indexed as

AgingAnimalsForecastingFree Radical ScavengersHumansReactive Oxygen SpeciesStem Cell TransplantationFree Radical ScavengersReactive Oxygen SpeciesAgingAnti-aging therapiesBiochemistryBiologySenescence

Identifiers

PMID27353257
PMCPMC5991498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.