Evidence map›Paper›PMID 27353255›Full record

ArticleAIDS research and human retroviruses

Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages.

Victoria E Walker-Sperling, Christian A Merlo, Robert W Buckheit, Allison Lambert, Patrick Tarwater, Greg D Kirk, M Bradley Drummond, Joel N Blankson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Victoria E Walker-Sperling1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Christian A Merlo1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Robert W Buckheit1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Allison Lambert1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Patrick Tarwater2 Division of Biostatistics and Epidemiology, Paul L. Foster School of Medicine , El Paso, Texas.
Greg D Kirk1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
M Bradley Drummond1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Joel N Blankson1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
Johns Hopkins Medicine · USJohns Hopkins University · USThe University of Texas at El Paso · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
CELLULAR &MOLECULAR MECH OF INFLAMMATORY REACTIONST32AI007247 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Joel L Pomerantz · 1985 to 2026
$10.2M
Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
The Study of HIV Infection in the Etiology of Lung Disease (SHIELD)R01HL090483 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2007 to 2011
$4.4M
Immune Mechanisms of HIV-associated COPDU01HL121814 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D, MCDYER, JOHN F · 2013 to 2017
$3.5M
Predictors, consequences and mechanisms of accelerated lung aging in HIVR01HL126549 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2014 to 2018
$3.2M
Patient-Oriented Research and Mentorship in HIV and Non-Communicable DiseasesK24AI118591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2015 to 2019
$766k
Mechanisms of COPD Subphenotype DevelopmentK23HL103192 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DRUMMOND, MICHAEL BRADLEY · 2010 to 2013
$650k
NCATS NIH HHS KL2 TR001077NHLBI NIH HHS K23 HL103192NHLBI NIH HHS R01 HL090483NHLBI NIH HHS R01 HL126549NHLBI NIH HHS T32 HL007534NHLBI NIH HHS U01 HL121814NIAID NIH HHS K24 AI118591NIAID NIH HHS P30 AI094189NIAID NIH HHS R21 AI096948NIDA NIH HHS R01 DA012568NIDA NIH HHS U01 DA036297NIGMS NIH HHS T32 GM008752
6 · The paper itself

Abstract

Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8

Indexed as

SurvivorsVirus ReplicationBronchoalveolar Lavage FluidCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHIV-1HIV InfectionsHumansMacrophages, Alveolaralveolar macrophagesCD8 T cellsCTLmonocyte derived macrophages

Identifiers

PMID27353255
PMCPMC5067835
OpenAlexW2530837323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.