ArticleScientific reports2016
Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Efficacy of biological response modifier lentinan with chemotherapy for advanced cancer: a meta-analysis.Cancer medicine · 2017Pooled it
- Comparative study on the therapeutic potential of aqueous extracts from commercially cultivated Agaricus bisporus and Lentinula edodes in Sri Lanka: antioxidant, anticancer, antidiabetic, and antibacterial properties.BMC complementary medicine and therapies · 2025Article
- Supplementation with Lentinan Improves the Colostrum Quality of Holstein Dairy Cows and the Immunity and Antioxidant Capacity of Newborn Calves.Animals : an open access journal from MDPI · 2025Article
- Lentinan enhances CAR-T cell potency in solid tumors by optimizing T cell differentiation.Frontiers in immunology · 2025Article
- Interplay of precision therapeutics and MD study: Calocybe indica's potentials against cervical cancer and its interaction with VEGF via octadecanoic acid.Journal of cellular and molecular medicine · 2024Article
- Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms.Journal of fungi (Basel, Switzerland) · 2024Review
- Potential promising anticancer applications of β-glucans: a review.Bioscience reports · 2024Review
- β-Glucan produced by Lentinus edodes suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals.Immunity, inflammation and disease · 2023Article
- Optimizing the synthesis of yeast Beta-glucan via response surface methodology for nanotechnology application.BMC microbiology · 2023Article
- Gastric precancerous lesions:occurrence, development factors, and treatment.Frontiers in oncology · 2023Review
- Review
- Recent advances in enzymatic synthesis of β-glucan and cellulose.Carbohydrate research · 2021Review
- β-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1α axis.Bioscience reports · 2020Article
- Article
- A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan-A Critical Review.Molecules (Basel, Switzerland) · 2019Review
- Production, structural characterization, and antiproliferative activity of exopolysaccharide produced by Scleroderma areolatum Ehrenb with different carbon source.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Lentinan up-regulates microRNA-340 to promote apoptosis and autophagy of human osteosarcoma cells.International journal of clinical and experimental pathology · 2018Article
- The β-glucan fromOncotarget · 2017Article
- Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-Glucans are well known for its various bioactivities, but the underlying mechanism has not been fully understood. This study focuses on the anti-tumor effect and the potential mechanism of a branched β-(1, 3)-glucan (LNT) extracted from Lentinus edodes. The in vivo data indicated that LNT showed a profound inhibition ratio of ~75% against S-180 tumor growth, even significantly higher than the positive control of Cytoxan (~54%). Interestingly, LNT sharply promoted immune cells accumulation into tumors accompanied by cell apoptosis and inhibition of cell proliferation during tumor development. Furthermore, LNT not only up-regulated expressions of the tumor suppressor p53, cell cycle arrestin p21 and pro-apoptotic proteins of Bax and caspase 3/9, but also down-regulated PARP1 and anti-apoptotic protein Bcl-2 expressions in tumor tissues. It was first found that LNT initiated p53-dependent signaling pathway to suppress cell proliferation in vitro, and the caspase-dependent pathway to induce cell apoptosis in vivo. The underlying anti-tumor mechanism was proposed that LNT activated immune responses to induce cell apoptosis through caspase 3-dependent signaling pathway and to inhibit cell proliferation possibly via p53-dependent signaling pathway in vivo. Besides, LNT inhibited angiogenesis by suppressing VEGF expression, leading to slow progression of tumors.
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