Evidence map›Paper›PMID 27353032›Full record

ArticleScientific reports2016

Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells.

Fábio Barrozo do Canto, Sylvia Maria Nicolau Campos, Alessandra Granato, Rafael F da Silva, Luciana Souza de Paiva, Alberto Nóbrega, Maria Bellio, Rita Fucs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fábio Barrozo do CantoUniversidade Federal do Rio de Janeiro (UFRJ), Centro de Ciências da Saúde, Instituto de Microbiologia Paulo de Góes (IMPG), Departamento de Imunologia, Laboratório Integrado de Imunobiologia - Rio de Janeiro/RJ, Brazil.
Sylvia Maria Nicolau CamposUniversidade Federal Fluminense (UFF), Instituto de Biologia, Departamento de Imunobiologia, Campus do Valonguinho, Outeiro de São João Batista, s/n. Niterói, RJ 24210-130 - Brazil.
Alessandra GranatoUniversidade Federal do Rio de Janeiro (UFRJ), Centro de Ciências da Saúde, Instituto de Microbiologia Paulo de Góes (IMPG), Departamento de Imunologia, Laboratório Integrado de Imunobiologia - Rio de Janeiro/RJ, Brazil.
Rafael F da SilvaUniversidade Federal Fluminense (UFF), Instituto de Biologia, Departamento de Imunobiologia, Campus do Valonguinho, Outeiro de São João Batista, s/n. Niterói, RJ 24210-130 - Brazil.
Luciana Souza de PaivaUniversidade Federal Fluminense (UFF), Instituto de Biologia, Departamento de Imunobiologia, Campus do Valonguinho, Outeiro de São João Batista, s/n. Niterói, RJ 24210-130 - Brazil.
Alberto NóbregaUniversidade Federal do Rio de Janeiro (UFRJ), Centro de Ciências da Saúde, Instituto de Microbiologia Paulo de Góes (IMPG), Departamento de Imunologia, Laboratório Integrado de Imunobiologia - Rio de Janeiro/RJ, Brazil.
Maria BellioUniversidade Federal do Rio de Janeiro (UFRJ), Centro de Ciências da Saúde, Instituto de Microbiologia Paulo de Góes (IMPG), Departamento de Imunologia, Laboratório Integrado de Imunobiologia - Rio de Janeiro/RJ, Brazil.
Rita FucsUniversidade Federal Fluminense (UFF), Instituto de Biologia, Departamento de Imunobiologia, Campus do Valonguinho, Outeiro de São João Batista, s/n. Niterói, RJ 24210-130 - Brazil.
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal inflammation can be induced by the reconstitution of T/B cell-deficient mice with low numbers of CD4(+) T lymphocytes depleted of CD25(+)Foxp3(+) regulatory T cells (Treg). Using RAG-knockout mice as recipients of either splenocytes exclusively depleted of CD25(+) cells or FACS-purified CD4(+)CD25(-)Foxp3(-) T cells, we found that the augmentation of potentially colitogenic naïve T cell numbers in the inoculum was unexpectedly beneficial for the suppression of colon disease and maintenance of immune homeostasis. Protection against T cell-mediated colitis correlated with a significant increment in the frequency of peripherally-induced CD4(+)CD25(+)Foxp3(+) T (pTreg) cells, especially in the mesenteric lymph nodes, an effect that required the presence of B cells and CD4(+)CD25(-)Foxp3(+) cells in physiological proportions. Our findings support a model whereby the interplay between B lymphocytes and a diversified naïve T cell repertoire is critical for the generation of CD4(+)CD25(+)Foxp3(+) pTreg cells and colitis suppression.

Indexed as

Models, ImmunologicalAnimalsB-LymphocytesColitisLymph NodesMesenteryMiceMice, KnockoutT-Lymphocytes, Regulatory

Identifiers

PMID27353032
PMCPMC4926115
OpenAlexW2470183454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.