ArticleJournal of evidence-based complementary & alternative medicine2017
Antidiabetic Mechanisms of Rosa canina Fruits: An In Vitro Evaluation.
Article in Journal of evidence-based complementary & alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response.Nutrition journal · 2018Trial
- Evaluation of the Potential Hypoglycemic and Neuroprotective Effects of Rosehip Fruit.Molecules (Basel, Switzerland) · 2026Article
- Investigation of the Efficacy of Orientin in Streptozotocin-Induced Type 1 Diabetes Model and Pancreatic Beta-TC6 Cells.Journal of biochemical and molecular toxicology · 2026Article
- Distinctive Behavior and Selective Modulation of PPARγ by Pentacyclic Triterpenoid Pomolic Acid and Hederagenin fromJournal of agricultural and food chemistry · 2026Article
- An oligosaccharide isolated from Rosa canina ameliorates lipid profile and liver damage in MASLD modeled rabbits: in vivo and in silico studies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- The Antidiabetic Activity of Wild-Growing and Cultivated Medicinal Plants Used in Romania for Diabetes Mellitus Management: A Phytochemical and Pharmacological Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Kinetic Modeling and Biological Activities ofAntioxidants (Basel, Switzerland) · 2025Article
- Review
- A Comprehensive Review on Phytochemistry and Pharmacology ofCurrent topics in medicinal chemistry · 2024Review
- Cytotoxic Impact of Naringenin-Loaded Solid Lipid Nanoparticles on RIN5F Pancreatic β CellsRecent advances in drug delivery and formulation · 2024Article
- Evidence-Based Anti-Diabetic Properties of Plant from the Occitan Valleys of the Piedmont Alps.Pharmaceutics · 2022Review
- Chemical constituents and pharmacological activities of medicinal plants fromChinese herbal medicines · 2022Review
- In Vitro Bioaccessibility of Bioactive Compounds from Rosehip-Enriched Corn Extrudates.Molecules (Basel, Switzerland) · 2022Article
- Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats.Research in pharmaceutical sciences · 2021Article
- Protective Effects of Hydroalcoholic Extract ofJournal of toxicology · 2021Article
- Medical Species Used in Russia for the Management of Diabetes and Related Disorders.Frontiers in pharmacology · 2021Review
- Anti-diabetic effect of a novel oligosaccharide isolated from Rosa canina via modulation of DNA methylation in Streptozotocin-diabetic rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Molecular mechanism of the anti-diabetic activity of an identified oligosaccharide fromResearch in pharmaceutical sciences · 2020Article
- Antidiabetic Potential ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- MechanisticPharmacognosy magazine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosa canina fruits have been used traditionally for the treatment of diabetes mellitus and its complications. The aim of current study was to evaluate the in vitro mechanism of action of R canina in managing diabetes mellitus. Cell proliferation and cytotoxicity assay were performed on pancreatic β-cells, βTC6. The protective activity of the extract on streptozotocin-induced death in βTC6 cells was studied. The effect of R canina on the metabolism of glucose in HepG2, a hepatocellular carcinoma cell line, was evaluated. The effect of the extract on glucose diffusion across the dialysis membrane, which is a comfortable model for assessing cellular glucose absorption, was evaluated. The results obtained from current study confirmed that R canina extract can act as a growth factor for pancreatic β-cell line providing a novel mechanism for the observed antidiabetic effect of this natural agent. Further preclinical studies are necessary to evaluate the perfect mechanism of action of R canina in diabetes mellitus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.