Evidence map›Paper›PMID 27352878›Full record

ArticleThe American journal of tropical medicine and hygiene2016

The First Confirmed Elimination of an Onchocerciasis Focus in Africa: Abu Hamed, Sudan.

Isam M A Zarroug, Kamal Hashim, Wigdan A ElMubark, Zainab A I Shumo, Kawthar A M Salih, Nuha A A ElNojomi, Huda A Awad, Nabil Aziz, Moses Katabarwa, Hassan K Hassan and 4 more

3 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517462 nacompletednot on this mapstarted 2018, after this paper: background citation

Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis

TypeinterventionalSponsorWashington University School of MedicineRan2018 to 2019Enrolled231ConditionsOnchocerciasisArmsIvermectin 3Mg Tab
NCT04188301 phase2completednot on this mapstarted 2019, after this paper: background citation

Safety and Efficacy of Combination Therapy With Ivermectin, Diethylcarbamazine, and Albendazole (IDA) for Individuals With Onchocerciasis

TypeinterventionalSponsorWashington University School of MedicineRan2019 to 2022Enrolled154ConditionsOnchocerciasisArmsIVM w/ ALB, Single dose of IDA, Three daily doses of IDA
NCT06070116 phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation

Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis

TypeinterventionalSponsorWashington University School of MedicineRan2024 to 2026Enrolled300ConditionsOnchocercal Subcutaneous Nodule, Onchocerciasis, Onchocerciasis, Ocular, Onchocerca InfectionArmsIvermectin w/ Albendazole, Ivermectin + Diethylcarbamazine + Albendazole, Moxidectin + Albendazole, Moxidectin + Diethylcarbamazine + Albendazole
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 208 citations in OpenAlex.

  1. Pooled it
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  15. Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
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  20. Scaling-Down Mass Ivermectin Treatment for Onchocerciasis Elimination: Modeling the Impact of the Geographical Unit for Decision Making.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Isam M A ZarrougMinistry of Health, Khartoum, Sudan.
Kamal HashimMinistry of Health, Khartoum, Sudan.
Wigdan A ElMubarkMinistry of Health, Khartoum, Sudan.
Zainab A I ShumoMinistry of Health, Khartoum, Sudan.
Kawthar A M SalihMinistry of Health, Khartoum, Sudan.
Nuha A A ElNojomiMinistry of Health, Khartoum, Sudan.
Huda A AwadMinistry of Health, Khartoum, Sudan.
Nabil AzizThe Carter Center, Khartoum, Sudan.
Moses KatabarwaThe Carter Center, Atlanta, Georgia.
Hassan K HassanGlobal Health Infectious Disease Research Program, College of Public Health, University of South Florida, Tampa, Florida.
Thomas R UnnaschGlobal Health Infectious Disease Research Program, College of Public Health, University of South Florida, Tampa, Florida.
Charles D MackenzieMichigan State University, Lancing, Michigan.
Frank RichardsThe Carter Center, Atlanta, Georgia.
Tarig B HigaziOhio University, Zanesville, Ohio. higazi@ohio.edu.
Federal Ministry of Health · SDCarter Center · USUniversity of South Florida · USMichigan State University · USOhio University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mass treatment with ivermectin for onchocerciasis was stopped in 2012 in Abu Hamed, an isolated focus on the River Nile in northern Sudan. A 3-year posttreatment surveillance (PTS) ensued, at the end of which an evaluation was conducted in 2015 following the current World Health Organization guidelines for verification of onchocerciasis elimination. Vector black flies were collected from sentinel breeding sites and finger-prick bloodspots were collected from children ≤ 10 years of age resident in 35 communities within the focus. Polymerase chain reaction (PCR) screening of 19,191 flies from four sites for the O-150 parasite-specific marker found no flies carrying Onchocerca volvulus larvae (0%, 95% upper confidence limit [UCL] = 0.16), and serological testing of 5,266 children identified only one Ov16 seropositive child (0.019%, 95% UCL = 0.074); whose skin snips were negative when tested by O-150 PCR assay. These results indicate that for the first time in Africa, onchocerciasis elimination has been verified after a successful PTS in Abu Hamed.

Indexed as

Communicable Disease ControlAnimalsCarrier ProteinsChildDNA, HelminthHelminth ProteinsHumansImmunoglobulin GInsect VectorsIvermectinOnchocerca volvulusOnchocerciasisPolymerase Chain ReactionSimuliidaeSudanCarrier ProteinsDNA, HelminthHelminth ProteinsImmunoglobulin GIvermectinOvd protein, Onchocerca volvulus

Identifiers

PMID27352878
PMCPMC5094213
OpenAlexW2473055721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.