ArticleIndian journal of pediatrics2016
Clinico - Laboratory Profile of Scrub Typhus - An Emerging Rickettsiosis in India.
Article in Indian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Etiology, Pathophysiology and Mortality of Shock in Children in Low (Middle) Income Countries: A Systematic Review.Journal of tropical pediatrics · 2022Pooled it
- Systematic review of the scrub typhus treatment landscape: Assessing the feasibility of an individual participant-level data (IPD) platform.PLoS neglected tropical diseases · 2021Pooled it
- Clinical profile and outcome of children with scrub typhus from Chennai, South India.European journal of pediatrics · 2018Trial
- Eyelid Swelling Revealing Scrub Typhus: Diagnostic Value of Eschar PCR.Indian journal of pediatrics · 2026Article
- Clinical Profile and Long-Term Outcomes of Scrub Typhus Meningoencephalitis in Children.Cureus · 2025Article
- Pediatric acute liver failure: Current perspective in etiology and management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Frequency and distribution of eschar in patients with scrub typhus in India: systematic review of literature and meta-analysis.Le infezioni in medicina · 2024Review
- Epidemiology, clinical characteristics, diagnosis, and complications of scrub typhus infection in Nepal: a systematic review.Annals of medicine and surgery (2012) · 2023Review
- Clinical profile and outcomes of pediatric scrub typhus associated with elevated hepatic transaminases.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Predictors of Severity of Scrub Typhus in Children Requiring Pediatric Intensive Care Admission.Journal of pediatric intensive care · 2022Article
- Clinical Profile and Predictors of Intensive Care Unit Admission in Pediatric Scrub Typhus: A Retrospective Observational Study from North India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Complex Cytokine Responses in Imported Scrub Typhus Cases, Germany, 2010-2018.The American journal of tropical medicine and hygiene · 2020Article
- Diagnostic tools used in the evaluation of acute febrile illness in South India: a scoping review.BMC infectious diseases · 2019Article
- Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India.Medicine and pharmacy reports · 2019Article
- Predictors of Severity in Pediatric Scrub Typhus.Indian journal of pediatrics · 2018Observational
- Immune thrombocytopenia with multi-organ dysfunction syndrome as a rare presentation of scrub typhus: a case report.BMC research notes · 2017Article
- Current Scenario of Pediatric Rickettsial Diseases.Indian journal of pediatrics · 2016Article
- Long-Segment Myelitis, Meningoencephalitis, and Axonal Polyneuropathy in a Case of Scrub Typhus.Annals of Indian Academy of NeurologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the clinical and laboratory profile of pediatric scrub typhus in rural south India.
methodsThis is a descriptive study of the clinical and laboratory features of 117 children with IgM ELISA proven scrub typhus out of 448 children, who were admitted in the Pediatric ward of a tertiary care hospital, during the study period of November 2014 through March 2015.
resultsFever was present in all 117 children, with mean duration of fever at admission as 9 d. Gastrointestinal tract was the most commonly affected system, seen in 51 % of children. Cough (82 %), myalgia (70 %), vomiting (68 %), headache (45 %) and pain abdomen (42 %) were the most common symptoms of scrub typhus. Hepatomegaly (70), splenomegaly (53 %), pallor (50 %) and eschar (41 %) were the common clinical findings in children with scrub typhus. Out of 49 children with eschar, 32 were associated with regional lymphadenopathy, which was commonly seen in axillary, neck and groin regions. Leucocytosis (50 %), anemia (56 %), increased SGOT / SGPT (47 %), thrombocytopenia (41 %), hypoalbuminemia (40 %) and hyponatremia (40 %) were the common lab features. Shock (46 %), myocarditis (24 %) and pneumonia (16 %) were the common complications seen in these children. This study showed that early treatment for scrub typhus results in a good outcome in terms of early recovery and nil mortality.
conclusionsRegional lymphadenopathy is a marker of hidden or developing eschar. Total count and differential count should be interpreted on the background of the duration of fever. Since IgM ELISA, which is diagnostic of scrub typhus may not be widely available, any febrile child coming from rural area with hepatosplenomegaly, pallor, eschar, generalised / regional lymphadenopathy, anemia, leucocytosis, thrombocytopenia and increased Aspartate transaminase (AST) /Alanine aminotransferase (ALT) should be started on empirical Doxycycline or Azithromycin in order to prevent life threatening complications secondary to delay in therapy.
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