Evidence map›Paper›PMID 27352781›Full record

ArticleCardiovascular diabetology2016

Association between omentin-1 expression in human epicardial adipose tissue and coronary atherosclerosis.

Yu Du, Qingwei Ji, Lun Cai, Fangjiong Huang, Yongqiang Lai, Yue Liu, Jianbo Yu, Bo Han, Enjun Zhu, Jinwei Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 127 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Epicardial Adipocytes in Cardiac Pathology and Healing.Cardiovascular drugs and therapy · 2025
    Review
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  6. Review
  7. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yu DuBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.
Qingwei JiDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Lun CaiBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.
Fangjiong HuangDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yongqiang LaiDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yue LiuDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Jianbo YuDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Bo HanDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Enjun ZhuDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Jinwei ZhangDepartment of Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yujie ZhouBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.
Zhijian WangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. zjwang1975@hotmail.com.
Yingxin ZhaoBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China. zyingxinmi@163.com.
Beijing Anzhen Hospital · CNBeijing Institute of Water · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOmentin-1, a novel adipocytokine mainly expressed in visceral adipose tissue, has been found to inhibit the inflammatory response and improve insulin resistance as well as other obesity-related disorders. This study investigated the association between omentin-1 expression in human epicardial adipose tissue (EAT) and coronary atherosclerosis.

methodsSerum samples, and paired biopsies from EAT and subcutaneous adipose tissue (SAT), were obtained from patients with and without coronary artery disease (CAD, n = 28 and NCAD, n = 12, respectively) during elective cardiac surgery. Coronary angiography was performed to identify CAD presence. Serum omentin-1 and adiponectin levels were measured by ELISA. mRNA expression of omentin-1 and adiponectin was detected in adipose tissue by quantitative real-time PCR, and omentin-1 protein expression was evaluated by immunohistochemistry. Correlation and multivariate linear regression analyses were performed to determine the association between omentin-1 expression and clinical risk factors.

resultsmRNA and protein expression of omentin-1 were higher in EAT than paired SAT in patients with CAD and NCAD. Compared with NCAD patients, CAD patients had lower omentin-1 and adiponectin mRNA levels in EAT and serum levels as well as lower omentin-1 protein levels. Among patients with CAD, omentin-1 expression was lower in EAT surrounding coronary segments with stenosis than those without stenosis, in terms of mRNA and protein, whereas adiponectin mRNA level in EAT did not seem to differ between stenotic and non-stenotic coronary segments in CAD patients. In multivariate linear regression analysis, CAD was an independent predictor of EAT omentin-1 mRNA expression (beta = -0.57, 95 % CI -0.89 to -0.24; P = 0.001) and serum omentin-1 levels (beta = -0.35, 95 % CI -0.67 to -0.03; P = 0.036).

conclusionsCirculating and EAT-derived omentin-1 levels were reduced in patients with CAD. Omentin-1 expression in patients with CAD was lower in EAT adjacent to coronary stenotic segments than non-stenotic segments.

Indexed as

AdipokinesAdipose TissueAdultAgedCoronary Artery DiseaseCytokinesFemaleGPI-Linked ProteinsHumansIntra-Abdominal FatLectinsMaleMiddle AgedObesityPericardiumReal-Time Polymerase Chain ReactionAdipokinesCytokinesGPI-Linked ProteinsITLN1 protein, humanLectinsAtherosclerosisCoronary artery diseaseEpicardial adipose tissueOmentin-1

Identifiers

PMID27352781
PMCPMC4924240
OpenAlexW2465213884

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.