ReviewDrug discovery today2016
Physiologically relevant human tissue models for infectious diseases.
Review in Drug discovery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Review
- One-step fabrication of 3D-aligned human skeletal muscle tissue and measurement of contractile force for preclinical drug testing.Materials today. Bio · 2025Article
- 3D human epithelial models: a promising platform for studyingFrontiers in cellular and infection microbiology · 2025Article
- Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.MedComm · 2025Article
- Model systems to studyFrontiers in cellular and infection microbiology · 2025Review
- AnJournal of virology · 2024Article
- In vitro high-content tissue models to address precision medicine challenges.Molecular aspects of medicine · 2023Review
- Small, Cationic Antifungal Proteins from Filamentous Fungi InhibitMicrobiology spectrum · 2022Article
- Tissue Models forFrontiers in cellular and infection microbiology · 2022Review
- A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine.Frontiers in cellular and infection microbiology · 2020Article
- Optimization of collagen type I-hyaluronan hybrid bioink for 3D bioprinted liver microenvironments.Biofabrication · 2018Article
- Engineered Human Contractile Myofiber Sheets as a Platform for Studies of Skeletal Muscle Physiology.Scientific reports · 2018Article
- Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.Scientific reports · 2018Article
- Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases.Cellular and molecular gastroenterology and hepatology · 2018Review
- Article
- Applications of Bioengineered 3D Tissue and Tumor Organoids in Drug Development and Precision Medicine: Current and Future.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2018Review
- Review
- Gastrointestinal microphysiological systems.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Experimental study of tuberculosis: From animal models to complex cell systems and organoids.PLoS pathogens · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research. Lack of suitable animal models, the need for better predictors of human immune responses and pathogens that grow poorly or not at all outside the human host impact our ability to study infectious agents that cause human disease, generation of essential tools for genetic manipulation of microbial pathogens and development of vaccines, therapeutics and host-targeted immunotherapies. The advent of conceptual and methodological advances in tissue engineering along with collaborative efforts between the bioengineering and infectious diseases scientific communities hold great promise to overcome these significant barriers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.