Evidence map›Paper›PMID 27352114›Full record

ReviewJournal of racial and ethnic health disparities2017

Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES.

Michelle T Duong, Brianna A Bingham, Paola C Aldana, Stephanie T Chung, Anne E Sumner

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of racial and ethnic health disparities, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Allostatic Load and Cardiovascular Disease: A Systematic Review.American journal of preventive medicine · 2025
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  13. Allostatic Load, Multimorbidity, and Overall and Cancer-Specific Survival among Older Adults in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michelle T DuongDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bld 10-CRC, Rm 6-5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD, 20892-1612, USA.
Brianna A BinghamDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bld 10-CRC, Rm 6-5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD, 20892-1612, USA.
Paola C AldanaDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bld 10-CRC, Rm 6-5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD, 20892-1612, USA.
Stephanie T ChungDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bld 10-CRC, Rm 6-5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD, 20892-1612, USA.
Anne E SumnerDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bld 10-CRC, Rm 6-5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD, 20892-1612, USA. annes@intra.niddk.nih.gov.

Funding

Heart Disease Risk Factors In African AmericansZIADK047023 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SUMNER, ANNE · 2009 to 2025
$16.3M
Heart Disease Risk Factors In African AmericansZ01DK047023 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SUMNER, ANNE E · 2002 to 2008
$500k
Intramural NIH HHS Z01 DK047023
6 · The paper itself

Abstract

After decades of resistance, there is now a genuine consensus that disease cannot be prevented or even successfully treated unless the role of stress is addressed alongside traditionally recognized factors such as genes and the environment. Measurement of allostatic load, which is quantified by the allostatic load score (ALS), is one of the most frequently used methods to assess the physiologic response to stress. Even though there is universal agreement that in the calculation of ALS, biomarkers from three categories should be included (cardiovascular, metabolic and immune), enormous variation exists in how ALS is calculated. Specifically, there is no consensus on which biomarkers to include or the method which should be used to determine whether the value of a biomarker represents high risk. In this perspective, we outline the approach taken in 21 different NHANES studies.

Indexed as

AllostasisBiomarkersBlood PressureC-Reactive ProteinHealth SurveysHumansRNA-Binding ProteinsStress, PsychologicalUnited StatesA1CF protein, humanBiomarkersC-Reactive ProteinRNA-Binding ProteinsA1CAllostatic load scoreBiomarkersBlood pressureC-reactive proteinStress

Identifiers

PMID27352114
PMCPMC5195908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.