ArticleInternational journal of hematology2016
Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization.
Article in International journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Clinical and etiological profile of anemia in a clinical hematology department of North Africa : A cross-sectional study.Leukemia research reports · 2026Article
- ESA-induced pure red cell aplasia presenting as a precipitous hemoglobin drop in end-stage renal disease.Archive of clinical cases · 2026Article
- Machine learning models in predictive factors for megaloblastic character of macrocytic anemia.Leukemia research reports · 2026Article
- LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2.Nature communications · 2025Article
- Clinical characteristic of isolated thrombocytopenia in patients with bone marrow failure-related germline variants: a retrospective study from a single centre.Annals of medicine · 2025Article
- Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions.Annals of medicine · 2025Review
- Complex association of mean corpuscular volume and outcomes in patients with aplastic anemia treated with cyclosporine A plus androgen or cyclosporine A alone.Clinical and experimental medicine · 2025Article
- Article
- Inverse Relationship between Mean Corpuscular Volume and T-Score in Chronic Dialysis Patients.Medicina (Kaunas, Lithuania) · 2022Article
- Double Robertsonian translocations in an infertile patient with macrocytic anemia: a case report.Molecular cytogenetics · 2020Article
- Impact of splicing factor mutations on clinical features in patients with myelodysplastic syndromes.International journal of hematology · 2018Article
- A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study.BMC cancer · 2018Article
- Etanercept-induced leukemia: could increased mean corpuscular volume be a predictor of hematologic malignancy?Rheumatology international · 2017Review
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15 authors at 10 institutions in 1 country.
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Abstract
There have been no studies on the distribution of causes of macrocytic anemia with respect to mean corpuscular volume (MCV) cutoff values. We retrospectively investigated the causes of macrocytic anemia (MCV ≥100 fL) among 628 patients who visited the outpatient hematology clinic in Tohoku University Hospital. To ensure data validity, we also analyzed data from 307 patients in eight other hospitals in the Tohoku district. The leading causes of macrocytic anemia (number of patients, %) were myelodysplastic syndromes (121, 19.3 %), suspected bone marrow failure syndromes (BMF; 74, 11.8 %), aplastic anemia (51, 8.1 %), plasma cell dyscrasia (45, 7.2 %), and vitamin B12 deficiency (40, 6.4 %) in Tohoku University Hospital. We made three primary findings as follows. First, the most common cause of macrocytic anemia is BMF. Second, lymphoid and solid malignancies are also common causes of macrocytosis. Third, macrocytic anemia may be classified into three groups: Group 1 (megaloblastic anemia and medications), which can exceed MCV 130 fL; Group 2 (alcoholism/liver disease, BMF, myeloid malignancy, and hemolytic anemia), which can exceed MCV 114 fL; and Group 3 (lymphoid malignancy, chronic renal failure, hypothyroidism, and solid tumors), which does not exceed MCV 114 fL. These conclusions were supported by the results from eight other hospitals.
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