Evidence map›Paper›PMID 27352075›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2016

The Neural Cell Adhesion Molecule-Derived (NCAM)-Peptide FG Loop (FGL) Mobilizes Endogenous Neural Stem Cells and Promotes Endogenous Regenerative Capacity after Stroke.

Rebecca Klein, Nicolas Mahlberg, Maurice Ohren, Anne Ladwig, Bernd Neumaier, Rudolf Graf, Mathias Hoehn, Morten Albrechtsen, Stephen Rees, Gereon Rudolf Fink and 2 more

Abstract read
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In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Montelukast reduced docetaxel-induced peripheral neuropathy in rats by altering oxidative stress, histopathological damage, and gene expressions.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  2. Article
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  4. Article
  5. The Role of Stem Cells in the Therapy of Stroke.Current neuropharmacology · 2022
    Review
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  8. Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Rebecca KleinDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. Rebecca.klein@uk-koeln.de.ORCID 0000-0002-4258-6965
Nicolas MahlbergDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Maurice OhrenDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Anne LadwigDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Bernd NeumaierMax Planck Institute for Metabolism Research, Cologne, Germany.
Rudolf GrafMax Planck Institute for Metabolism Research, Cologne, Germany.
Mathias HoehnMax Planck Institute for Metabolism Research, Cologne, Germany.
Morten AlbrechtsenEnkam Pharmaceuticals A/S, Copenhagen, Denmark.
Stephen ReesEnkam Pharmaceuticals A/S, Copenhagen, Denmark.
Gereon Rudolf FinkDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Maria Adele RuegerDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Michael SchroeterDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Max Planck Institute for Metabolism Research · DEForschungszentrum Jülich · DEEnkam (Denmark) · DKUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural cell adhesion molecule (NCAM)-derived peptide FG loop (FGL) modulates synaptogenesis, neurogenesis, and stem cell proliferation, enhances cognitive capacities, and conveys neuroprotection after stroke. Here we investigated the effect of subcutaneously injected FGL on cellular compartments affected by degeneration and regeneration after stroke due to middle cerebral artery occlusion (MCAO), namely endogenous neural stem cells (NSC), oligodendrocytes, and microglia. In addition to immunohistochemistry, we used non-invasive positron emission tomography (PET) imaging with the tracer [

Indexed as

AnimalsCell MovementCells, CulturedInjections, SubcutaneousMaleNerve RegenerationNeural Cell Adhesion MoleculesNeural Stem CellsNeurogenesisPeptidesPositron-Emission TomographyRatsRats, WistarStrokeFGLL peptideNeural Cell Adhesion MoleculesPeptides[18F]-fluoro-L-thymidineFG loopNCAMNCAM-derived peptideNeuroinflammationPositron-emission-tomographyRegenerationStroke

Identifiers

PMID27352075
OpenAlexW2473700204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.