Evidence map›Paper›PMID 27352014›Full record

ReviewCurrent environmental health reports2016

Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.

Natalie G Exum, Nora Pisanic, Douglas A Granger, Kellogg J Schwab, Barbara Detrick, Margaret Kosek, Andrey I Egorov, Shannon M Griffin, Christopher D Heaney

Abstract readReview
In one paragraph

Review in Current environmental health reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Influence of the ProtozoanInternational journal of molecular sciences · 2024
    Review
  5. Disease Biomarkers of Giardiasis.Journal of parasitology research · 2022
    Review
  6. Article
  7. Review
  8. Child Salivary SIgA and Its Relationship to Enteric Infections and EED Biomarkers in Maputo, Mozambique.International journal of environmental research and public health · 2020
    Article
  9. Article
  10. Article
  11. Plasmonic gold chips for the diagnosis of Toxoplasma gondii, CMV, and rubella infections using saliva with serum detection precision.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  12. Article
  13. Observational
  14. Article
  15. Review
  16. Article
  17. The salivary gland as a target for enhancing immunization response.Tropical diseases, travel medicine and vaccines · 2017
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalie G ExumDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Nora PisanicDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Douglas A GrangerInstitute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
Kellogg J SchwabDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Barbara DetrickDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Margaret KosekDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Andrey I EgorovNational Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Shannon M GriffinNational Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA.
Christopher D HeaneyDepartment of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. cheaney1@jhu.edu.

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
Non-Invasive Zoonotic Pathogen Exposure & Outcome BiomarkersK01OH010193 · OH · JOHNS HOPKINS UNIVERSITY · PI HEANEY, CHRISTOPHER D · 2012 to 2014
$324k
NIEHS NIH HHS T32 ES007141NIOSH CDC HHS K01 OH010193
6 · The paper itself

Abstract

purpose of reviewThis review discusses the utility of pathogen-specific antibody biomarkers for improving estimates of the population burden of waterborne infections, assessing the fraction of infections that can be prevented by specific water treatments, and understanding transmission routes and the natural history and ecology of disease in different populations (including asymptomatic infection rates). RECENT

findingsWe review recent literature on the application of pathogen-specific antibody response data to estimate incidence and prevalence of acute infections and their utility to assess the contributions of waterborne transmission pathways. Advantages and technical challenges associated with the use of serum versus minimally invasive salivary antibody biomarkers in cross-sectional and prospective surveys are discussed. We highlight recent advances and challenges and outline future directions for research, development, and application of antibody-based and other immunological biomarkers of waterborne infections.

Indexed as

AntibodiesWater MicrobiologyBiomarkersHumansIncidenceWaterborne DiseasesWater PollutionAntibodiesBiomarkersAntibodiesBiomarkersImmunoconversionPathogensSalivaSerologyWaterborne infections

Identifiers

PMID27352014
PMCPMC5424709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.