ArticlePloS one2016
Possible Mechanisms Underlying Aging-Related Changes in Early Diastolic Filling and Long Axis Motion-Left Ventricular Length and Blood Pressure.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Mitral annular plane systolic excursion to left atrial volume ratio as a novel index to assess ventricular filling pressure in dogs with myxomatous mitral valve disease.Veterinary research communications · 2026Article
- A systematic review of long-term cardiotoxic effects of treatment in survivors of childhood acute lymphoblastic leukemia.Molecular and cellular pediatrics · 2025Review
- The reduction of the left ventricular long-axis early diastolic peak velocity (e') evident by early-middle age occurs in the absence of aging-related slowing of active relaxation.European journal of applied physiology · 2024Article
- Mechanisms and implications of sex differences in cardiac aging.The journal of cardiovascular aging · 2022Article
- Determinants of left ventricular structure, filling and long axis function in systemic sclerosis.PloS one · 2021Article
- Relationships of global longitudinal strain with s`, long-axis systolic excursion, left ventricular length and heart rate.PloS one · 2020Article
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- Left ventricular structural and functional changes in Friedreich ataxia - Relationship with body size, sex, age and genetic severity.PloS one · 2019Article
- Cardiovascular sexual dimorphism in a diet-induced type 2 diabetes rodent model, the Nile rat (Arvicanthis niloticus).PloS one · 2018Article
- Differences in the determinants of right ventricular and regional left ventricular long-axis dysfunction in Friedreich ataxia.PloS one · 2018Article
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5 authors.
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Abstract
backgroundThe transmitral E wave and the peak velocity of early diastolic mitral annular motion (e`) both decrease with age, but the mechanisms underlying these age-related changes are incompletely understood. This study investigated the possible contributions of blood pressure (BP) and left ventricular end-diastolic length (LVEDL) to age-related reductions in E and e`.
methodsThe study group were 82 healthy adult subjects <55 years of age who were not obese or hypertensive. Transmitral flow and mitral annular motion were recorded using pulsed-wave Doppler. LVEDL was measured from the mitral annular plane to the apical endocardium.
resultsAge was positively correlated with diastolic BP and septal wall thickness (SWT), inversely correlated with LVEDL (β = -0.25) after adjustment for sex and body surface area, but was not related to left ventricular end-diastolic diameter (LVEDD). Age was also inversely correlated with E (r = -0.36), septal e`(r = -0.53) and lateral e`(r = -0.53). On multivariable analysis, E was inversely correlated with diastolic BP and LVEDD, septal e`was inversely correlated with diastolic BP and positively correlated with SWT and LVEDL, after adjusting for body mass index, whilst lateral e`was inversely correlated with diastolic BP and positively correlated with LVEDL.
conclusionThe above findings are consistent with higher BP being a contributor to age-related reductions in both E and e`and shortening of LVEDL with age being a contributor to the age-related reduction in e`. An implication of these findings is that slowing of myocyte relaxation is unlikely to be the sole, and may not be the main, mechanism underlying age-related decreases in E and e`.
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