Evidence map›Paper›PMID 27351742›Full record

ArticlePloS one2016

A Case-Control Study on the Risk Factors for Meningococcal Disease among Children in Greece.

Christos Hadjichristodoulou, George Mpalaouras, Vasiliki Vasilopoulou, Antonios Katsioulis, George Rachiotis, Kalliopi Theodoridou, Georgia Tzanakaki, Vassiliki Syriopoulou, Maria Theodoridou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Christos HadjichristodoulouDepartment of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
George MpalaourasDepartment of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Vasiliki VasilopoulouAghia Sophia Children's Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
Antonios KatsioulisDepartment of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
George RachiotisDepartment of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Kalliopi TheodoridouAghia Sophia Children's Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
Georgia TzanakakiNational Reference Centre for Meningitis, National School of Public Health, Athens, Greece.
Vassiliki SyriopoulouAghia Sophia Children's Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
Maria TheodoridouAghia Sophia Children's Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of Thessaly · GRNational School of Public Health · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to identify environmental or genetic risk factors that are associated with invasive meningococcal disease (IMD) in children in Greece.

methodsA case-control study was performed in 133 children (44 cases and 89 controls) aged between 0-14 years, who were hospitalized in a children's hospital in Athens. Demographics and possible risk factors were collected by the use of a structured questionnaire. To investigate the association of mannose binding lectin (MBL) with IMD, a frequency analysis of the haplotypes of the MBL2 gene and quantitative measurement of MBL serum protein levels were performed using Nanogen NanoChipR 400 technology and immuno-enzyme techniques, respectively.

resultsThe multivariate analysis revealed that changes in a child's life setting (relocation or vacation, OR = 7.16), paternal smoking (OR = 4.51), upper respiratory tract infection within the previous month (OR = 3.04) and the density of people in the house/100m2 (OR = 3.16), were independent risk factors associated with IMD. Overall 18.8% of patients had a MBL2 genotype with low functionality compared to 10.1% of healthy controls, but this was not statistically significant (p = 0.189).

conclusionPrevention strategies aimed at reducing parental smoking and other risk factors identified in this study could decrease the risk of IMD among children in Greece.

Indexed as

AdolescentCase-Control StudiesChildChild, PreschoolFemaleGenotypeGreeceHaplotypesHumansInfantMaleMannose-Binding LectinMeningococcal InfectionsRespiratory Tract InfectionsTobacco Smoke PollutionMannose-Binding LectinMBL2 protein, humanTobacco Smoke Pollution

Identifiers

PMID27351742
PMCPMC4924850
OpenAlexW2471021658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.