Evidence map›Paper›PMID 27351678›Full record

Trial reportRadiology2016

Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain.

Pavel Rodriguez, Wei Zhou, Douglas W Barrett, Wilson Altmeyer, Juan E Gutierrez, Jinqi Li, Jack L Lancaster, Francisco Gonzalez-Lima, Timothy Q Duong

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Methylene blue inhibits GABANeuropharmacology · 2017
    Article
  16. Effects of GABABehavioral and brain functions : BBF · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pavel RodriguezFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Wei ZhouFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Douglas W BarrettFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Wilson AltmeyerFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Juan E GutierrezFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Jinqi LiFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Jack L LancasterFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Francisco Gonzalez-LimaFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
Timothy Q DuongFrom the Research Imaging Institute (P.R., W.Z., J.L., J.L.L., T.Q.D.) and Department of Radiology (P.R., W.A., J.E.G.), The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Dr, San Antonio, TX 78229; and Department of Psychology and Institute for Neuroscience, The University of Texas at Austin, Austin, Tex (D.W.B., F.G.L.).
The University of Texas Health Science Center at San Antonio · USThe University of Texas at Austin · US

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon, Elena Volpi · 2015 to 2026
$14.1M
NCATS NIH HHS UL1 TR001120NIA NIH HHS P30 AG044271
6 · The paper itself

Abstract

Purpose To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain. Materials and Methods The institutional review board approved this prospective, HIPAA-compliant, randomized, double-blinded, placebo-controlled clinical trial, and all patients provided informed consent. Twenty-six subjects (age range, 22-62 years) were enrolled. Functional magnetic resonance (MR) imaging was performed with a psychomotor vigilance task (sustained attention) and delayed match-to-sample tasks (short-term memory) before and 1 hour after administration of low-dose methylene blue or a placebo. Cerebrovascular reactivity effects were also measured with the carbon dioxide challenge, in which a 2 × 2 repeated-measures analysis of variance was performed with a drug (methylene blue vs placebo) and time (before vs after administration of the drug) as factors to assess drug × time between group interactions. Multiple comparison correction was applied, with cluster-corrected P < .05 indicating a significant difference. Results Administration of methylene blue increased response in the bilateral insular cortex during a psychomotor vigilance task (Z = 2.9-3.4, P = .01-.008) and functional MR imaging response during a short-term memory task involving the prefrontal, parietal, and occipital cortex (Z = 2.9-4.2, P = .03-.0003). Methylene blue was also associated with a 7% increase in correct responses during memory retrieval (P = .01). Conclusion Low-dose methylene blue can increase functional MR imaging activity during sustained attention and short-term memory tasks and enhance memory retrieval.

Indexed as

Administration, OralAdultAttentionDouble-Blind MethodEnzyme InhibitorsFemaleHealthy VolunteersHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMethylene BlueMiddle AgedProspective StudiesPsychomotor PerformanceEnzyme InhibitorsMethylene Blue

Identifiers

PMID27351678
PMCPMC5084971
OpenAlexW2475052555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.