Evidence map›Paper›PMID 27351565›Full record

SynthesisWorld journal of pediatrics : WJP2016

Meta-analysis of risk factors associated with atherosclerosis in patients with Kawasaki disease.

Han Zhang, Ming-Guo Xu, Li-Jian Xie, Min Huang, Jie Shen, Ting-Ting Xiao

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in World journal of pediatrics : WJP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Kawasaki Disease: Pathology, Risks, and Management.Vascular health and risk management · 2022
    Review
  5. Article
  6. An Update on Cardiovascular Risk Factors After Kawasaki Disease.Frontiers in cardiovascular medicine · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Han ZhangDepartment of Cardiology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
Ming-Guo XuDepartment of Cardiovascular Center, Shenzhen Children's Hospital, Shenzhen, China.
Li-Jian XieDepartment of Cardiology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China. naijileix@aliyun.com.
Min HuangDepartment of Cardiology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
Jie ShenDepartment of Cardiology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
Ting-Ting XiaoDepartment of Cardiology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
Shanghai Children's Hospital · CNShenzhen Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKawasaki disease (KD) has now become the leading cause of acquired heart disease among children in developed countries. This study investigated whether patients with KD have an increased risk of atherosclerosis.

methodsElectronic databases, including PubMed, Embase and Springer link, were searched through June 1, 2015, for eligible studies. Studies were included when they met the following criteria: 1) an observational study focusing on evaluating the risk factors for atherosclerosis in patients with KD; 2) KD was diagnosed clinically according to the Japan Kawasaki Disease Research Committee or American Heart Association's diagnostic criteria; 3) the study subjects were KD patients without coronary heart disease or related cardiovascular disease (KD group) and non-KD patients as control (control group), and 4) investigation of important atherosclerosis risk factors, total cholesterol (TC), low-density lipoprotein cholesterol (LDL), triglycerides (TG), systolic blood pressure (SBP), and flowmediated dilatation (FMD). The methodological quality of the included studies was evaluated using the Newcastle- Ottawa Scale. Mean difference (MD) and relative risk (RR) and corresponding 95% confidence intervals (CI) were used to calculate the pooled results.

resultsSixteen studies were included with a total of 870 patients, including 421 KD patients and 449 non-KD controls. Differences in TG and SBP between KD patients and controls were not significant; in contrast, TC and LDL levels were significantly higher in KD patients than the controls, whereas FMD in the KD patients was significantly lower.

conclusionsKD patients may have an increased risk of developing atherosclerosis.

Indexed as

AdolescentAtherosclerosisCase-Control StudiesChildCholesterolComorbidityDisease ProgressionFemaleHumansJapanMaleMucocutaneous Lymph Node SyndromeRisk FactorsSurvival RateCholesterolatherosclerosisflow-mediated dilatationKawasaki diseasemeta-analysistotal cholesterol

Identifiers

PMID27351565
OpenAlexW2473030139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.