ArticleScientific reports2016
Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Plants as Enrichment? The Effect of Live Plants on the Behavior and Welfare of Indoor-Housed Titi Monkeys (Plecturocebus cupreus).American journal of primatology · 2026Article
- Zebrafish as a Model Organism for Post-Traumatic Stress Disorder: Insights into Stress Mechanisms and Behavioral Assays.Biology · 2025Review
- Housing Conditions Affect Adult Zebrafish (Animals : an open access journal from MDPI · 2023Article
- Structural environmental enrichment and the way it is offered influence cognitive judgement bias and anxiety-like behaviours in zebrafish.Animal cognition · 2023Article
- Optimizing zebrafish rearing-Effects of fish density and environmental enrichment.Frontiers in behavioral neuroscience · 2023Article
- Habitat complexity and predator odours impact on the stress response and antipredation behaviour in coral reef fish.PloS one · 2023Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish.Frontiers in endocrinology · 2022Article
- Review
- Two-Photon Laser Ablation and In Vivo Wide-Field Imaging of Inferior Olive Neurons Revealed the Recovery of Olivocerebellar Circuits in Zebrafish.International journal of environmental research and public health · 2021Article
- Extracellular matrix remodeling with stress and depression: Studies in human, rodent and zebrafish models.The European journal of neuroscience · 2021Review
- Enrichment for Laboratory Zebrafish-A Review of the Evidence and the Challenges.Animals : an open access journal from MDPI · 2021Review
- The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models.ILAR journal · 2020Article
- Article
- Divergent action of fluoxetine in zebrafish according to responsivity to novelty.Scientific reports · 2018Article
- Behavioral and Biochemical Effects of N-Acetylcysteine in Zebrafish Acutely Exposed to Ethanol.Neurochemical research · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we provide evidence that both pharmacological and environmental manipulations similarly blunt the cortisol release in response to an acute stressor in adult zebrafish. Different groups of fish were maintained isolated or group-housed in barren or enriched tanks, and then exposed or not to diazepam or fluoxetine. Acute stress increased cortisol levels in group-housed zebrafish maintained in barren environment. Single-housed zebrafish displayed a blunted cortisol response to stress. Environmental enrichment also blunted the stress response and this was observed in both isolated and group-housed fish. The same blunting effect was observed in zebrafish exposed to diazepam or fluoxetine. We highlighted environmental enrichment as an alternative and/or complimentary therapeutic for reducing stress and as a promoter of animal welfare.
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Registered trials
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