Evidence map›Paper›PMID 27351286›Full record

SynthesisOncotarget2016

An overall and dose-response meta-analysis for thyrotropin and thyroid cancer risk by histological type.

Na Hu, Zhan-Ming Li, Jin-Feng Liu, Zhen-Zhen Zhang, Li-Shun Wang

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Higher thyroid hormone levels and cancer.European journal of nuclear medicine and molecular imaging · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Na HuInstitute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
Zhan-Ming LiRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, P.R. China.
Jin-Feng LiuInstitute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
Zhen-Zhen ZhangInstitute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
Li-Shun WangInstitute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
Fudan University · CNShanghai Jiao Tong University · CNTaishan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyrotropin (TSH) is thought as a risk factor for thyroid cancer. However, the effect of serum TSH might depend on histological types of thyroid cancer. We searched for related studies including serum TSH as an exposure and thyroid cancer as a result in PUBMED, EMBASE and Chinese National Knowledge Infrastructure up to April 21, 2016. This meta-analysis included 22 articles with 53,538 participants. When comparing all histological thyroid cancer, the pooled odds ratios of thyroid cancer in patients with nodules was found to increase significantly with higher serum TSH concentrations for differentiated thyroid carcinoma (1.88 vs .1.48, P = 0.0000) and papillary thyroid carcinoma (2.08 vs. 1.48, P = 0.0006). Each 1 mU/L increase of serum TSH was associated with 14% greater risk of thyroid cancer for all histological thyroid cancer, 16% for differentiated thyroid carcinoma and 22% for papillary thyroid carcinoma. In addition, high serum TSH was associated with a reduced risk for follicular thyroid carcinoma (OR = 0.73, 95% CI: 0.52, 1.02). This meta-analysis suggested high serum TSH concentration is risky for papillary thyroid carcinoma but not for follicular thyroid carcinoma.

Indexed as

HumansRisk FactorsThyroid NeoplasmsThyrotropinThyrotropindifferentiated thyroid carcinomameta-analysispapillary thyroid carcinomaserum thyrotropinthyroid cancer

Identifiers

PMID27351286
PMCPMC5216976
OpenAlexW2468531639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.