ArticleeLife2016
Co-expression of Foxa.a, Foxd and Fgf9/16/20 defines a transient mesendoderm regulatory state in ascidian embryos.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Less, but More: New Insights From Appendicularians on Chordate Fgf Evolution and the Divergence of Tunicate Lifestyles.Molecular biology and evolution · 2025Article
- A digital twin reproducing gene regulatory network dynamics of early Ciona embryos indicates robust buffers in the network.PLoS genetics · 2023Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Article
- Conditional specification of endomesoderm.Cells & development · 2021Review
- Single-cell analysis of cell fate bifurcation in the chordate Ciona.BMC biology · 2021Article
- The gene regulatory system for specifying germ layers in early embryos of the simple chordate.Science advances · 2021Article
- Neuromesodermal Lineage Contribution to CNS Development in Invertebrate and Vertebrate Chordates.Genes · 2021Review
- Using linkage logic theory to control dynamics of a gene regulatory network of a chordate embryo.Scientific reports · 2021Article
- Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships.PLoS genetics · 2021Article
- A single-cell analysis of the molecular lineage of chordate embryogenesis.Science advances · 2020Article
- Tunicate gastrulation.Current topics in developmental biology · 2020Review
- Multiple inputs into a posterior-specific regulatory network in the Ciona notochord.Developmental biology · 2019Article
- The Ciona myogenic regulatory factor functions as a typical MRF but possesses a novel N-terminus that is essential for activity.Developmental biology · 2019Article
- Controlling Cell Fate Specification System by Key Genes Determined from Network Structure.iScience · 2018Article
- Depletion of Maternal Cyclin B3 Contributes to Zygotic Genome Activation in the Ciona Embryo.Current biology : CB · 2018Article
- The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm.Developmental biology · 2018Article
- Cas9-mediated excision ofDevelopment (Cambridge, England) · 2017Article
- Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many bilaterian embryos, nuclear β-catenin (nβ-catenin) promotes mesendoderm over ectoderm lineages. Although this is likely to represent an evolutionary ancient developmental process, the regulatory architecture of nβ-catenin-induced mesendoderm remains elusive in the majority of animals. Here, we show that, in ascidian embryos, three nβ-catenin transcriptional targets, Foxa.a, Foxd and Fgf9/16/20, are each required for the correct initiation of both the mesoderm and endoderm gene regulatory networks. Conversely, these three factors are sufficient, in combination, to produce a mesendoderm ground state that can be further programmed into mesoderm or endoderm lineages. Importantly, we show that the combinatorial activity of these three factors is sufficient to reprogramme developing ectoderm cells to mesendoderm. We conclude that in ascidian embryos, the transient mesendoderm regulatory state is defined by co-expression of Foxa.a, Foxd and Fgf9/16/20.
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