ArticleInternational scholarly research notices2014
Detection of Abnormal Hemoglobin Variants by HPLC Method: Common Problems with Suggested Solutions.
Article in International scholarly research notices, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
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- Tackling sickle cell crisis in Nigeria: the need for newer therapeutic solutions in sickle cell crisis management - short communication.Annals of medicine and surgery (2012) · 2023Article
- Can HPLC be used as an ideal methodology instead of Hb Electrophoresis for the diagnosis of hemoglobinopathies in a routine clinical laboratory of under-resource country like Nepal? Is the change necessary?Annals of medicine and surgery (2012) · 2022Article
- Techniques for the Detection of Sickle Cell Disease: A Review.Micromachines · 2021Review
- The curious case of hemoglobin DC disease masquerading as sickle cell anemia.Hematology reports · 2020Article
- Retracted: Detection of Abnormal Hemoglobin Variants by HPLC Method: Common Problems with Suggested Solutions.International scholarly research notices · 2015Article
- Prevalence of hemoglobinopathies using high-performance liquid chromatography as diagnostic tool in anemic patients of tertiary care center of Western India.Asian journal of transfusion scienceArticle
- Challenges Associated with the Identification of Abnormal Hemoglobin Variants Utilizing the High-performance Liquid Chromatograph Technique: A Prospective Study in a Hospital Setting in Gujarat.International journal of applied & basic medical researchArticle
Corrections and comments
- Retraction · 2015-04-16Lack of Approval from Author · Plagiarism of Data ·
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thalassemia and thalassemic hemoglobinopathies pose serious health problem leading to severe morbidity and mortality in Indian population. Plethora of hemoglobin variants is prevalent in multiethnic Indian population. The aim of the present study was to analyze laboratory aspects, namely, hematological profile and HPLC findings of the hemoglobin variants detected, and to discuss problems that we faced in diagnosis in a routine clinical laboratory. We screened a total of 4800 cases in a hospital based population of North India in a 2-years period of by automated HPLC method using the Variant Hemoglobin Testing System (Variant II Beta Thalassemia Short Program, Bio-Rad Laboratories) under the experimental conditions specified by the manufacturer. Whole blood in EDTA was used and red cell indices were determined using automated hematology analyzer. We detected 290 cases with abnormal variants in which beta thalassemia was the most common followed by hemoglobin E. Here, we discuss the laboratory aspects of various hemoglobin disorders and diagnostic difficulties in cases like borderline HbA2 values, presence of silent mutation, alpha thalassemia gene, and few rare variants which at times require correlation with genetic study. Special attention was given to HbA2 level even in presence of a structural variant to rule out coinheritance of beta thalassemia gene.
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Registered trials
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