Evidence map›Paper›PMID 27350878›Full record

ReviewClinical & translational immunology2016

Neural regulation of cancer: from mechanobiology to inflammation.

Tae-Hyung Kim, Amy C Rowat, Erica K Sloan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical & translational immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Anesthesia and cancer recurrence: an overview.Journal of anesthesia, analgesia and critical care · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Melanoma in the Eyes of Mechanobiology.Frontiers in cell and developmental biology · 2020
    Review
  11. Review
  12. Review
  13. Article
  14. Interfacial Adipose Tissue in Systemic Sclerosis.Current rheumatology reports · 2017
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Tae-Hyung KimCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Amy C RowatDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA; The Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Erica K SloanCousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; The Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia; Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.
University of California, Los Angeles · US

Funding

Adrenergic regulation of tumor inflammation and metastatic disseminationR01CA160890 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLOAN, ERICA KATE · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA160890
6 · The paper itself

Abstract

Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment strategies require a more comprehensive understanding of underlying regulatory mechanisms. Recently, the sympathetic nervous system (SNS) has been implicated in cancer progression and beta-blockers have been identified as a novel strategy to limit metastasis. This review discusses evidence that SNS signaling regulates metastasis by modulating the physical characteristics of tumor cells, tumor-associated immune cells and the extracellular matrix (ECM). Altered mechanotype is an emerging hallmark of cancer cells that is linked to invasive phenotype and treatment resistance. Mechanotype also influences crosstalk between tumor cells and their environment, and may thus have a critical role in cancer progression. First, we discuss how neural signaling regulates metastasis and how SNS signaling regulates both biochemical and mechanical properties of tumor cells, immune cells and the ECM. We then review our current knowledge of the mechanobiology of cancer with a focus on metastasis. Next, we discuss links between SNS activity and tumor-associated inflammation, the mechanical properties of immune cells, and how the physical properties of the ECM regulate cancer and metastasis. Finally, we discuss the potential for clinical translation of our knowledge of cancer mechanobiology to improve diagnosis and treatment.

Identifiers

PMID27350878
PMCPMC4910118
OpenAlexW2372077962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.